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glud1b glutamate dehydrogenase 1b [ Danio rerio (zebrafish) ]

Gene ID: 373092, updated on 2-Nov-2024

Summary

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Official Symbol
glud1bprovided by ZNC
Official Full Name
glutamate dehydrogenase 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030828-1
See related
Ensembl:ENSDARG00000101074 AllianceGenome:ZFIN:ZDB-GENE-030828-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb719; glud1; zgc:55630; wu:fb16e02; wu:fb58f12; wu:fe37f03; wu:fj43f02; zgc:192851
Summary
Predicted to enable glutamate dehydrogenase (NAD+) activity. Predicted to be involved in glutamate catabolic process. Predicted to act upstream of or within amino acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; fin; mesoderm; muscle; and tail bud. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to human GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See glud1b in Genome Data Viewer
Location:
chromosome: 12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (25845494..25881944)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (25754134..25790584)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene protein kinase C, epsilon a Neighboring gene endothelial PAS domain protein 1a Neighboring gene si:dkey-193p11.2 Neighboring gene synuclein, gamma b (breast cancer-specific protein 1)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential Apoptotic and Mitogenic Effects of Lectins in Zebrafish. Wang K, et al. Front Endocrinol (Lausanne), 2019. PMID 31231312, Free PMC Article
  2. Induction of Phosphoenolpyruvate Carboxykinase (PEPCK) during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes. Furukawa F, et al. Int J Biol Sci, 2015. PMID 25999794, Free PMC Article
  3. Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests mitochondrial dysfunction to play a key role in PFOA toxicity. Hagenaars A, et al. Chemosphere, 2013 May. PMID 23427857
  4. FOXN3 Regulates Hepatic Glucose Utilization. Karanth S, et al. Cell Rep, 2016 Jun 21. PMID 27292639, Free PMC Article
  5. Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. Wu X, et al. Int J Mol Sci, 2022 Apr 11. PMID 35457018, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC192851

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glutamate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutamate dehydrogenase 1b
NP_955839.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199545.4 → NP_955839.2  glutamate dehydrogenase 1b

    See identical proteins and their annotated locations for NP_955839.2

    Status: VALIDATED

    Source sequence(s)
    CR931998, CU459179
    UniProtKB/TrEMBL
    A0A0R4IMI7, Q6P3L9, Q6PUR2
    Related
    ENSDARP00000135641.1, ENSDART00000170582.2
    Conserved Domains (3) summary
    cd01076
    Location:247 → 532
    NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
    pfam00208
    Location:247 → 530
    ELFV_dehydrog; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
    pfam02812
    Location:97 → 224
    ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    25845494..25881944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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