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Ddx24 DEAD-box helicase 24 [ Rattus norvegicus (Norway rat) ]

Gene ID: 373065, updated on 27-Nov-2024

Summary

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Symbol
Ddx24provided by RGD
Full Name
DEAD-box helicase 24provided by RGD
Primary source
RGD:727929
See related
EnsemblRapid:ENSRNOG00000009166 AllianceGenome:RGD:727929
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be active in nucleolus. Orthologous to human DDX24 (DEAD-box helicase 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 223.6), Brain (RPKM 203.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ddx24 in Genome Data Viewer
Location:
6q32
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128329554..128346818, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (122564767..122582032, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127302201..127319382, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549032 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2 Neighboring gene interferon, alpha-inducible protein 27 Neighboring gene interferon, alpha-inducible protein 27 like 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DExD/H-box RNA helicases in ribosome biogenesis. Martin R, et al. RNA Biol, 2013 Jan. PMID 22922795, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX24
Names
ATP-dependent RNA helicase DDX24-like
DEAD (Asp-Glu-Ala-Asp) box helicase 24
DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
NP_954550.1
XP_006240545.1
XP_006240546.1
XP_063118313.1
XP_063118314.1
XP_063118315.1
XP_063118316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199119.1 → NP_954550.1  ATP-dependent RNA helicase DDX24

    See identical proteins and their annotated locations for NP_954550.1

    Status: PROVISIONAL

    Source sequence(s)
    AY341876
    UniProtKB/TrEMBL
    A0A8I6AFW4, A6JEM9, F7ETB4, Q6VEU8
    Related
    ENSRNOP00000012256.2, ENSRNOT00000012256.5
    Conserved Domains (3) summary
    COG0513
    Location:191 → 735
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00271
    Location:567 → 675
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:194 → 505
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    128329554..128346818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240483.3 → XP_006240545.1  ATP-dependent RNA helicase DDX24 isoform X1

    See identical proteins and their annotated locations for XP_006240545.1

    UniProtKB/TrEMBL
    A0A8I6AFW4, A6JEM9, F7ETB4, Q6VEU8
    Conserved Domains (3) summary
    COG0513
    Location:191 → 735
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00271
    Location:567 → 675
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:194 → 505
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_063262243.1 → XP_063118313.1  ATP-dependent RNA helicase DDX24 isoform X1

    UniProtKB/TrEMBL
    A6JEM9, F7ETB4, Q6VEU8

  3. XM_063262244.1 → XP_063118314.1  ATP-dependent RNA helicase DDX24 isoform X1

    UniProtKB/TrEMBL
    A6JEM9, F7ETB4, Q6VEU8

  4. XM_063262245.1 → XP_063118315.1  ATP-dependent RNA helicase DDX24 isoform X1

    UniProtKB/TrEMBL
    A6JEM9, F7ETB4, Q6VEU8

  5. XM_006240484.4 → XP_006240546.1  ATP-dependent RNA helicase DDX24 isoform X1

    See identical proteins and their annotated locations for XP_006240546.1

    UniProtKB/TrEMBL
    A0A8I6AFW4, A6JEM9, F7ETB4, Q6VEU8
    Conserved Domains (3) summary
    COG0513
    Location:191 → 735
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00271
    Location:567 → 675
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:194 → 505
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. XM_063262246.1 → XP_063118316.1  ATP-dependent RNA helicase DDX24 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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