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Hsl Hormone-sensitive lipase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37289, updated on 9-Dec-2024

Summary

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Official Symbol
Hslprovided by FlyBase
Official Full Name
Hormone-sensitive lipaseprovided by FlyBase
Primary source
FLYBASE:FBgn0034491
Locus tag
Dmel_CG11055
See related
AllianceGenome:FB:FBgn0034491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
A; anon-56Ea; CG11055; dhsl; dHSL; Dmel\CG11055; DmHSL; hsl; HSL
Summary
Predicted to enable monoacylglycerol lipase activity; sterol ester esterase activity; and triacylglycerol lipase activity. Involved in triglyceride mobilization. Located in cytosol. Is active in lipid droplet. Is expressed in adult head; embryonic/larval gut; and organism. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Hsl in Genome Data Viewer
Location:
56F11-56F11; 2-90 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20257650..20261726)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16145155..16149231)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Arginyltransferase 1 Neighboring gene Proliferating cell nuclear antigen Neighboring gene plutonium

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success. Heier C, et al. Elife, 2021 Feb 4. PMID 33538247, Free PMC Article
  2. The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein. Axton JM, et al. EMBO J, 1994 Jan 15. PMID 8313891, Free PMC Article
  3. Membrane attachment and structure models of lipid storage droplet protein 1. Lin P, et al. Biochim Biophys Acta, 2014 Mar. PMID 24333382, Free PMC Article
  4. Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization. Bi J, et al. J Cell Sci, 2012 Aug 1. PMID 22505614
  5. RNA-seq analysis of diet-driven obesity and anti-obesity effects of quercetin glucoside or epigallocatechin gallate in Drosophila adults. Azuma M, et al. Eur Rev Med Pharmacol Sci, 2019 Jan. PMID 30720195

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success.
    Title: Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables monoacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sterol ester esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride mobilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Hormone-sensitive lipase
Names
CG11055-PA
CG11055-PB
CG11055-PC
Hormone-sensitive lipase ortholog
Hsl-PA
Hsl-PB
Hsl-PC
hormone sensitive lipase
transcription unit A
NP_611463.1
NP_725941.1
NP_725942.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20257650..20261726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137619.3 → NP_611463.1  Hormone-sensitive lipase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611463.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JR83
    Related
    FBpp0085582
    Conserved Domains (3) summary
    COG0657
    Location:350 → 537
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:51 → 376
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:395 → 539
    Abhydrolase; alpha/beta hydrolases

  2. NM_166381.2 → NP_725941.1  Hormone-sensitive lipase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725941.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JR83
    Related
    FBpp0085583
    Conserved Domains (3) summary
    COG0657
    Location:350 → 537
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:51 → 376
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:395 → 539
    Abhydrolase; alpha/beta hydrolases

  3. NM_166382.2 → NP_725942.1  Hormone-sensitive lipase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725942.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JR83
    Related
    FBpp0085584
    Conserved Domains (3) summary
    COG0657
    Location:350 → 537
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:51 → 376
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:395 → 539
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JR83 Q7JR83
Q960T4 Q960T4

Gene LinkOut

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