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Hacl 2-hydroxyacyl-CoA lyase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37285, updated on 4-Jan-2025

Summary

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Official Symbol
Haclprovided by FlyBase
Official Full Name
2-hydroxyacyl-CoA lyaseprovided by FlyBase
Primary source
FLYBASE:FBgn0034488
Locus tag
Dmel_CG11208
See related
AllianceGenome:FB:FBgn0034488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.196; CG11208; Dmel\CG11208; HACL1
Summary
Predicted to enable 2-hydroxyacyl-CoA lyase activity and thiamine pyrophosphate binding activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to be active in peroxisome. Is expressed in several structures, including adult head; anlage in statu nascendi; embryonic/larval midgut primordium; gut section; and head epidermis primordium. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Hacl in Genome Data Viewer
Location:
56F11-56F11; 2-90 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20242752..20245388, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16130257..16132893, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene EF-hand domain containing 1.2 Neighboring gene pickpocket 6 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila. Rahman A, et al. Cell Rep, 2022 May 31. PMID 35649355, Free PMC Article
  2. Sequencing mRNA from cryo-sliced Drosophila embryos to determine genome-wide spatial patterns of gene expression. Combs PA, et al. PLoS One, 2013. PMID 23951250, Free PMC Article
  3. Drosophila ventral furrow morphogenesis: a proteomic analysis. Gong L, et al. Development, 2004 Feb. PMID 14711877
  4. The quantitative genetic basis of male mating behavior in Drosophila melanogaster. Moehring AJ, et al. Genetics, 2004 Jul. PMID 15280239, Free PMC Article
  5. Absolute Quantification of Proteins in the Eye of Drosophila melanogaster. Raghuraman BK, et al. Proteomics, 2020 Dec. PMID 32663363

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 2-hydroxyacyl-CoA lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid alpha-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid alpha-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
2-hydroxyacyl-CoA lyase
Names
2-hydroxyacyl-CoA lyase 1
CG11208-PA
Hacl-PA
NP_611460.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20242752..20245388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137616.3 → NP_611460.1  2-hydroxyacyl-CoA lyase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611460.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3B7
    Related
    FBpp0085630
    Conserved Domains (4) summary
    cd07035
    Location:8 → 161
    TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins
    PRK09259
    Location:8 → 552
    PRK09259; putative oxalyl-CoA decarboxylase; Validated
    cd02004
    Location:367 → 550
    TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...
    pfam00205
    Location:195 → 322
    TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3B7 Q7K3B7

Gene LinkOut

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