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18w 18 wheeler [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37277, updated on 9-Dec-2024

Summary

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Official Symbol
18wprovided by FlyBase
Official Full Name
18 wheelerprovided by FlyBase
Primary source
FLYBASE:FBgn0287775
Locus tag
Dmel_CG8896
See related
AllianceGenome:FB:FBgn0287775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
18-w; 18-wheeler; 18W; CG8896; CT25100; Dmel\CG8896; EP-709; l(2)00053; tlr; toll; toll-2; Toll-2; Toll2
Summary
Predicted to enable transmembrane signaling receptor activity. Involved in several processes, including antibacterial humoral response; convergent extension; and oogenesis. Located in plasma membrane. Is expressed in several structures, including epithelium; follicle cell; gut section; imaginal disc; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See 18w in Genome Data Viewer
Location:
56F8-56F8; 2-90 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20111511..20116932)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15999016..16004437)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44632 Neighboring gene long non-coding RNA:CR44633 Neighboring gene long non-coding RNA:CR44634 Neighboring gene long non-coding RNA:CR44635

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Monitoring positional information during oogenesis in adult Drosophila. Fasano L, et al. Development, 1988 Oct. PMID 2855515
  2. The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll. Eldon E, et al. Development, 1994 Apr. PMID 7600965
  3. Expression of 18-wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila. Kleve CD, et al. Dev Dyn, 2006 Jul. PMID 16607637
  4. Effect of major abdominal surgery on endotoxin release and expression of Toll-like receptors 2/4. Buttenschoen K, et al. Langenbecks Arch Surg, 2009 Mar. PMID 18546014
  5. Roles of Toll-like receptors in innate immune responses. Takeda K, et al. Genes Cells, 2001 Sep. PMID 11554921

See all (153) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Median mRNA expression of TLR2 and TLR4 of mononuclear cells was not altered, and there was no obvious trend over time.
    Title: Effect of major abdominal surgery on endotoxin release and expression of Toll-like receptors 2/4.
  2. 18W protein plays an adhesive or signaling role in regions of the epithelium engaged in cell migration.
    Title: Expression of 18-wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila.
  3. Data show that in larvae, 18wheeler is required for normal fat body development, and in mutant larvae induction of all antimicrobial peptide genes is compromised.
    Title: Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antibacterial humoral response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in antimicrobial humoral response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axis elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in convergent extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in eggshell formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral cord development HMP PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
18 wheeler
Names
18-wheeler
18Wheeler
18w-PA
CG8896-PA
Toll-2
toll like receptor
toll receptor
wheeler

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20111511..20116932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057466.2 → NP_476814.1  18 wheeler [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476814.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBR2, Q2XXS4
    Related
    FBpp0085620, FBtr0086309
    Conserved Domains (6) summary
    smart00082
    Location:679 → 736
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:1045 → 1183
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:210 → 464
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:212 → 236
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:866 → 907
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:235 → 295
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBR2 A1ZBR2
Q24591 Q24591
Q2XXS4 Q2XXS4
Q7JPR9 Q7JPR9
Q961H0 Q961H0

Gene LinkOut

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