Toll-7 Toll-7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Toll-7provided by FlyBase
Official Full Name: Toll-7provided by FlyBase
Primary source: FLYBASE:FBgn0034476
Locus tag: Dmel_CG8595
See related: AllianceGenome:FB:FBgn0034476
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8595; CT24947; Dmel\CG8595; dTLR7; dToll7; Tl-7; toll; Toll; Toll 7; TOLL 7; toll-7; Toll7
Summary: Enables neurotrophin receptor activity; transmembrane signaling receptor activity; and virion binding activity. Involved in several processes, including Toll signaling pathway; regulation of defense response; and response to virus. Located in external side of plasma membrane. Is expressed in several structures, including adult head; adult olfactory antennal lobe glomerulus; cuboidal/columnar epithelium; ganglia; and head epidermis primordium. Orthologous to human CHADL (chondroadherin like) and VASN (vasorin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19826578..19832973)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15714083..15720478)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables neurotrophin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pattern recognition receptor activity	IC Inferred by Curator more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables virion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface pattern recognition receptor signaling pathway	IC Inferred by Curator more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of virus	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

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