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JUNB JunB proto-oncogene, AP-1 transcription factor subunit [ Homo sapiens (human) ]

Gene ID: 3726, updated on 27-Nov-2024

Summary

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Official Symbol
JUNBprovided by HGNC
Official Full Name
JunB proto-oncogene, AP-1 transcription factor subunitprovided by HGNC
Primary source
HGNC:HGNC:6205
See related
Ensembl:ENSG00000171223 MIM:165161; AllianceGenome:HGNC:6205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP-1
Summary
Enables sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor AP-1 complex. Implicated in head and neck squamous cell carcinoma and melanoma. Biomarker of gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and lymphoma (multiple). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See JUNB in Genome Data Viewer
Location:
19p13.13
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12791486..12793315)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12915978..12917807)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12902300..12904129)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene bestrophin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12876343-12876888 Neighboring gene hook microtubule tethering protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12881756-12882256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12882257-12882757 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12885288-12885968 Neighboring gene CRISPRi-FlowFISH-validated DNASE2 and PRDX2 regulatory element Neighboring gene CRISPRi-FlowFISH-validated PRDX2 regulatory element 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14077 Neighboring gene CRISPRi-FlowFISH-validated PRDX2 regulatory element 2 Neighboring gene CRISPRi-FlowFISH-validated JUNB and PRDX2 regulatory element 1 Neighboring gene CRISPRi-FlowFISH-validated JUNB and PRDX2 regulatory element 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14079 Neighboring gene CRISPRi-FlowFISH-validated JUNB regulatory element Neighboring gene microRNA 5684 Neighboring gene CRISPRi-FlowFISH-validated PRDX2 regulatory element 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10173 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12904163-12904664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14083 Neighboring gene CRISPRi-FlowFISH-validated RNASEH2A regulatory element Neighboring gene peroxiredoxin 2 Neighboring gene thrombospondin type 1 domain containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitogen-activated protein kinase signaling controls basal and oncostatin M-mediated JUNB gene expression. Hicks MJ, et al. Mol Cell Biochem, 2015 May. PMID 25662951
  2. DNA methylation does not regulate JUNB expression in CML: comment on "Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia" by Hoshino et al. [Leuk. Res. 33 (2009) 1361-1366]. Strathdee G, et al. Leuk Res, 2010 May. PMID 20006998
  3. The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment. Fan F, et al. Leukemia, 2017 Jul. PMID 27890927
  4. [Expression and functional analysis of transcriptional factor JunB in hepatic cancer cells]. Wang L, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2010 Jan. PMID 20056077
  5. Over-expression of JunB inhibits mitochondrial stress and cytotoxicity in human lymphoma cells exposed to chronic oxidative stress. Son YO, et al. BMB Rep, 2010 Jan. PMID 20132737

See all (213) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual therapeutic targeting of MYC and JUNB transcriptional programs for enhanced anti-myeloma activity.
    Title: Dual therapeutic targeting of MYC and JUNB transcriptional programs for enhanced anti-myeloma activity.
  2. Comprehensive Analysis of CXCR4, JUNB, and PD-L1 Expression in Circulating Tumor Cells (CTCs) from Prostate Cancer Patients.
    Title: Comprehensive Analysis of CXCR4, JUNB, and PD-L1 Expression in Circulating Tumor Cells (CTCs) from Prostate Cancer Patients.
  3. JunB condensation attenuates vascular endothelial damage under hyperglycemic condition.
    Title: JunB condensation attenuates vascular endothelial damage under hyperglycemic condition.
  4. Spatiotemporal Transcriptome Analysis Reveals Activation of the AP1 Pathway in the Ovarian Microenvironment during the Transition from Premenopause to Postmenopause.
    Title: Spatiotemporal Transcriptome Analysis Reveals Activation of the AP1 Pathway in the Ovarian Microenvironment during the Transition from Premenopause to Postmenopause.
  5. The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture.
    Title: The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture.
  6. AP-1 signaling modulates cardiac fibroblast stress responses.
    Title: AP-1 signaling modulates cardiac fibroblast stress responses.
  7. JUNB mediates oxaliplatin resistance via the MAPK signaling pathway in gastric cancer by chromatin accessibility and transcriptomic analysis.
    Title: JUNB mediates oxaliplatin resistance via the MAPK signaling pathway in gastric cancer by chromatin accessibility and transcriptomic analysis.
  8. Transcription Factor JunB Suppresses Hepatitis C Virus Replication.
    Title: Transcription Factor JunB Suppresses Hepatitis C Virus Replication.
  9. Shock drives a STAT3 and JunB-mediated coordinated transcriptional and DNA methylation response in the endothelium.
    Title: Shock drives a STAT3 and JunB-mediated coordinated transcriptional and DNA methylation response in the endothelium.
  10. Glial AP1 is activated with aging and accelerated by traumatic brain injury.
    Title: Glial AP1 is activated with aging and accelerated by traumatic brain injury.
Submit: New GeneRIF Correction See all GeneRIFs (95)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of jun B proto-oncogene (JUNB) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of JunB is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed
matrix gag HIV-1 matrix activates monocytes to produce MCP-1, which depends on the binding activity of AP-1 complexes (c-Fos/JunB) in the MCP-1 promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in decidualization IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
  
involved_in integrated stress response signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoclast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of T-helper 17 cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to steroid hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in trophectodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of transcription factor AP-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor JunB
Names
activator protein 1
jun B proto-oncogene
transcription factor AP-1 subunit JunB
transcription factor jun-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002229.3 → NP_002220.1  transcription factor JunB

    See identical proteins and their annotated locations for NP_002220.1

    Status: VALIDATED

    Source sequence(s)
    AC018761, BC009466
    Consensus CDS
    CCDS12280.1
    UniProtKB/Swiss-Prot
    P17275, Q96GH3
    UniProtKB/TrEMBL
    Q53HP8, Q5U079
    Related
    ENSP00000303315.4, ENST00000302754.6
    Conserved Domains (2) summary
    cd14696
    Location:270 → 329
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
    pfam03957
    Location:5 → 257
    Jun; Jun-like transcription factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12791486..12793315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12915978..12917807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17275.1 GenPept UniProtKB/Swiss-Prot:P17275

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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