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sm smooth [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37254, updated on 9-Dec-2024

Summary

Official Symbol
smprovided by FlyBase
Official Full Name
smoothprovided by FlyBase
Primary source
FLYBASE:FBgn0003435
Locus tag
Dmel_CG9218
See related
AllianceGenome:FB:FBgn0003435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH10856; CG9218; Dmel\CG9218; l(2)05338; Sm; smo
Summary
Predicted to enable mRNA binding activity. Involved in adult feeding behavior; axon guidance; and determination of adult lifespan. Located in nucleoplasm. Is expressed in several structures, including Y chromosome loop; adult brain cell body rind; adult head; ganglia; and larval nervous system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to several human genes including HNRNPLL (heterogeneous nuclear ribonucleoprotein L like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

Location:
56D15-56E1; 2-90 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19517864..19631508, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15405369..15519013, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 56c Neighboring gene Ionotropic receptor 56d Neighboring gene transfer RNA:Glutamic acid-TTC 1-3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44473 Neighboring gene long non-coding RNA:CR44474 Neighboring gene Tubulin tyrosine ligase-like 6A Neighboring gene long non-coding RNA:CR44503 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in adult feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleoplasm HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
smooth
Names
CG9218-PA
CG9218-PAA
CG9218-PAB
CG9218-PAC
CG9218-PB
CG9218-PE
CG9218-PG
CG9218-PH
CG9218-PI
CG9218-PJ
CG9218-PK
CG9218-PL
CG9218-PM
CG9218-PO
CG9218-PP
CG9218-PT
CG9218-PU
CG9218-PV
CG9218-PW
CG9218-PY
CG9218-PZ
sm-PA
sm-PAA
sm-PAB
sm-PAC
sm-PB
sm-PE
sm-PG
sm-PH
sm-PI
sm-PJ
sm-PK
sm-PL
sm-PM
sm-PO
sm-PP
sm-PT
sm-PU
sm-PV
sm-PW
sm-PY
sm-PZ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19517864..19631508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259505.2NP_001246434.1  smooth, isoform AA [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246434.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K8A2
    Conserved Domains (3) summary
    cd12424
    Location:275346
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:393475
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:75160
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  2. NM_001259497.2NP_001246426.1  smooth, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246426.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K852
    Conserved Domains (3) summary
    cd12424
    Location:264335
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:382464
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  3. NM_001259500.2NP_001246429.1  smooth, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246429.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K8A1
    Conserved Domains (3) summary
    cd12424
    Location:282353
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:400482
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:75160
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  4. NM_001274164.1NP_001261093.1  smooth, isoform AB [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261093.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF04
    Conserved Domains (3) summary
    cd12424
    Location:276347
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:394476
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  5. NM_001259498.2NP_001246427.1  smooth, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246427.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7B0
    Conserved Domains (3) summary
    cd12424
    Location:263334
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:381461
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  6. NM_001259495.2NP_001246424.1  smooth, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246424.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5AEJ9
    Conserved Domains (2) summary
    cd12424
    Location:231302
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:349431
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  7. NM_166368.5NP_725913.2  smooth, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725913.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHD5
    Conserved Domains (3) summary
    cd12424
    Location:201272
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:319401
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cl17169
    Location:51119
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. NM_057383.7NP_476731.1  smooth, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476731.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMZ7
    Related
    FBpp0085681
    Conserved Domains (3) summary
    cd12424
    Location:242313
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:360442
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  9. NM_001259494.2NP_001246423.1  smooth, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246423.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7H8
    Conserved Domains (3) summary
    cd12424
    Location:302373
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:420502
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  10. NM_001259496.2NP_001246425.1  smooth, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246425.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7W3
    Conserved Domains (3) summary
    cd12424
    Location:259330
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:377459
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  11. NM_001259499.2NP_001246428.1  smooth, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246428.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7I2
    Conserved Domains (3) summary
    cd12424
    Location:319390
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:437519
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  12. NM_001032268.3NP_001027439.2  smooth, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027439.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NND8
    Conserved Domains (3) summary
    cd12424
    Location:247318
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:365447
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  13. NM_001259501.2NP_001246430.1  smooth, isoform V [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246430.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7W7
    Conserved Domains (3) summary
    cd12424
    Location:307378
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:425507
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  14. NM_001032269.3NP_001027440.1  smooth, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027440.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMZ7
    Conserved Domains (3) summary
    cd12424
    Location:242313
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:360442
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  15. NM_001259504.2NP_001246433.1  smooth, isoform Z [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246433.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7I6
    Conserved Domains (3) summary
    cd12424
    Location:258329
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:376458
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  16. NM_001259502.2NP_001246431.1  smooth, isoform W [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246431.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E914
    Conserved Domains (2) summary
    cd12424
    Location:2798
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:145227
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  17. NM_001043096.2NP_001036561.1  smooth, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036561.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E914
    Conserved Domains (2) summary
    cd12424
    Location:2798
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:145227
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  18. NM_001259503.2NP_001246432.1  smooth, isoform Y [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246432.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E914
    Conserved Domains (2) summary
    cd12424
    Location:2798
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:145227
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  19. NM_001274165.1NP_001261094.1  smooth, isoform AC [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261094.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEV0
    Conserved Domains (2) summary
    cd12424
    Location:68139
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:186268
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  20. NM_166369.5NP_725914.1  smooth, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBN3
    Related
    FBpp0085684
    Conserved Domains (2) summary
    cd12424
    Location:171242
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:289371
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
  21. NM_166370.5NP_725915.2  smooth, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725915.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBN4, Q8IHH3
    Conserved Domains (2) summary
    cd12424
    Location:187258
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:305387
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins