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Fak - Focal adhesion kinase

Enables non-membrane spanning protein tyrosine kinase activity. Involved in negative regulation of receptor recycling and negative regulation of synaptic assembly at neuromuscular junction. Located in focal adhesion; type Ib terminal bouton; and type Is terminal bouton. Is expressed in several structures, including brain; cephalic furrow; egg chamber; follicle cell; and midgut primordium. Human ortholog(s) of this gene implicated in breast cancer; hypertension; leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to several human genes including PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa