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EndoB Endophilin B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37218, updated on 9-Dec-2024

Summary

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Official Symbol
EndoBprovided by FlyBase
Official Full Name
Endophilin Bprovided by FlyBase
Primary source
FLYBASE:FBgn0034433
Locus tag
Dmel_CG9834
See related
AllianceGenome:FB:FBgn0034433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9834; D-endoB; D-EndoB; Dmel\CG9834; endoB
Summary
Involved in clathrin-dependent endocytosis involved in vitellogenesis and membrane organization. Located in membrane. Is expressed in several structures, including adult head; embryonic antennal sense organ; female germline cell; and ganglia. Orthologous to several human genes including SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See EndoB in Genome Data Viewer
Location:
56C10-56C10; 2-88 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19307447..19310665, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15194952..15198170, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene TAK1-associated binding protein 2 Neighboring gene Acyl-CoA dehydrogenase very long chain Neighboring gene Rad, Gem/Kir family member 1 Neighboring gene uncharacterized protein Neighboring gene wurstfest

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An encore for kiss and run? Marte B. Nat Cell Biol, 2002 May. PMID 11988753
  2. Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction. Guichet A, et al. EMBO J, 2002 Apr 2. PMID 11927550, Free PMC Article
  3. Endophilin-B regulates autophagy during synapse development and neurodegeneration. Hernandez-Diaz S, et al. Neurobiol Dis, 2022 Feb. PMID 34933093
  4. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Chang KT, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805187, Free PMC Article
  5. The CHD Protein Kismet Restricts the Synaptic Localization of Cell Adhesion Molecules at the Drosophila Neuromuscular Junction. Smith IR, et al. Int J Mol Sci, 2024 Mar 6. PMID 38474321, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endophilin-B regulates autophagy during synapse development and neurodegeneration.
    Title: Endophilin-B regulates autophagy during synapse development and neurodegeneration.
  2. These results allow us to conclude that D-EndoB contributes to the endocytic activity downstream of Oskar by facilitating membrane dynamics through its N-BAR domain.
    Title: Endophilin B is required for the Drosophila oocyte to endocytose yolk downstream of Oskar.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis involved in vitellogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane tubulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vitellogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
endophilin B
Names
CG9834-PA
CG9834-PB
CG9834-PC
CG9834-PD
EndoB-PA
EndoB-PB
EndoB-PC
EndoB-PD
Endophilin-B
endophilin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19307447..19310665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166340.3 → NP_725873.1  endophilin B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725873.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGU0, Q8T389, Q9V8T2
    Related
    FBpp0085743
    Conserved Domains (2) summary
    cd07594
    Location:26 → 254
    BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
    cd11802
    Location:315 → 366
    SH3_Endophilin_B; Src homology 3 domain of Endophilin-B

  2. NM_001103906.3 → NP_001097376.1  endophilin B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097376.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYJ0
    Conserved Domains (2) summary
    cd07594
    Location:26 → 254
    BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
    cl17036
    Location:325 → 354
    SH3; Src Homology 3 domain superfamily

  3. NM_137566.4 → NP_611410.1  endophilin B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611410.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGU0, Q8SYD9
    Related
    FBpp0085742
    Conserved Domains (2) summary
    cd07594
    Location:26 → 266
    BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
    cd11802
    Location:327 → 378
    SH3_Endophilin_B; Src homology 3 domain of Endophilin-B

  4. NM_001103905.3 → NP_001097375.1  endophilin B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097375.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYJ1
    Conserved Domains (2) summary
    cd07594
    Location:26 → 266
    BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
    cl17036
    Location:337 → 366
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYJ0 A8DYJ0
A8DYJ1 A8DYJ1
Q8IGU0 Q8IGU0
Q8SYD9 Q8SYD9
Q8T389 Q8T389

Gene LinkOut

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