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Acadvl Acyl-CoA dehydrogenase very long chain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37217, updated on 9-Dec-2024

Summary

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Official Symbol
Acadvlprovided by FlyBase
Official Full Name
Acyl-CoA dehydrogenase very long chainprovided by FlyBase
Primary source
FLYBASE:FBgn0034432
Locus tag
Dmel_CG7461
See related
AllianceGenome:FB:FBgn0034432
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg7461; CG7461; dACADVL; Dmel\CG7461
Summary
Predicted to enable fatty-acyl-CoA binding activity; long-chain fatty acyl-CoA dehydrogenase activity; and very-long-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic salivary gland duct; larval muscle system; and salivary gland body primordium. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Acadvl in Genome Data Viewer
Location:
56C9-56C10; 2-88 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19305172..19307445)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15192677..15194950)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Myb-interacting protein 40 Neighboring gene TAK1-associated binding protein 2 Neighboring gene Endophilin B Neighboring gene Rad, Gem/Kir family member 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Acyl-CoA dehydrogenases: Dynamic history of protein family evolution. Swigonová Z, et al. J Mol Evol, 2009 Aug. PMID 19639238, Free PMC Article
  2. Genetic variants regulating expression levels and isoform diversity during embryogenesis. Cannavò E, et al. Nature, 2017 Jan 19. PMID 28024300
  3. A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Geuking P, et al. Genetics, 2005 Dec. PMID 16079232, Free PMC Article
  4. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Musselman LP, et al. Dis Model Mech, 2011 Nov. PMID 21719444, Free PMC Article
  5. Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Palanker L, et al. Cell Metab, 2009 Mar. PMID 19254568, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables very-long-chain fatty acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables very-long-chain fatty acyl-CoA dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Acyl-CoA dehydrogenase very long chain
Names
Acadvl-PB
Acadvl-PC
CG7461-PB
CG7461-PC
drosophila very-long chain ACAD
NP_001286611.1
NP_611409.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19305172..19307445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299682.1 → NP_001286611.1  Acyl-CoA dehydrogenase very long chain, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286611.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBJ2, C9QPI7
    Conserved Domains (2) summary
    cd01161
    Location:45 → 454
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:67 → 446
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

  2. NM_137565.3 → NP_611409.2  Acyl-CoA dehydrogenase very long chain, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611409.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBJ2, C9QPI7
    Conserved Domains (2) summary
    cd01161
    Location:45 → 454
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:67 → 446
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBJ2 A1ZBJ2

Gene LinkOut

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