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5-HT1B - 5-hydroxytryptamine (serotonin) receptor 1B

Enables G protein-coupled serotonin receptor activity. Involved in G protein-coupled serotonin receptor signaling pathway; entrainment of circadian clock; and serotonin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including Kenyon cell; brain; dopaminergic PPL1 neuron; ellipsoid body layer; and synaptic neuropil domain. Used to study generalized anxiety disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; anxiety disorder (multiple); depressive disorder (multiple); and substance abuse (multiple). Orthologous to several human genes including HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to 5-HT1B

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Species Gene Architecture aa