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GEFmeso Guanine nucleotide exchange factor in mesoderm [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37134, updated on 4-Jan-2025

Summary

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Official Symbol
GEFmesoprovided by FlyBase
Official Full Name
Guanine nucleotide exchange factor in mesodermprovided by FlyBase
Primary source
FLYBASE:FBgn0050115
Locus tag
Dmel_CG30115
See related
AllianceGenome:FB:FBgn0050115
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18430; CG30115; CG5503; Dmel\CG30115
Summary
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in imaginal disc-derived appendage morphogenesis; positive regulation of stem cell proliferation; and regulation of signal transduction. Is expressed in several structures, including anterior endoderm; dorsal vessel primordium; embryonic/larval midgut primordium; imaginal disc; and somatic trunk mesoderm derivative. Orthologous to several human genes including PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See GEFmeso in Genome Data Viewer
Location:
55D3-55E1; 2-86 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18554119..18611777, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14441624..14499282, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46271 Neighboring gene uncharacterized protein Neighboring gene Phosphoenolpyruvate carboxykinase 1 Neighboring gene Rad, Gem/Kir family member 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structured RhoGEF recruitment drives myosin II organization on large exocytic vesicles. Kamalesh K, et al. J Cell Sci, 2024 Jul 1. PMID 38899547, Free PMC Article
  2. Rac1 is a novel interactor of Drosophila guanine nucleotide exchange factor GEFmeso. Sundaram S. Mol Cell Biochem, 2015 Jun. PMID 25753922
  3. Novel guanine nucleotide exchange factor GEFmeso of Drosophila melanogaster interacts with Ral and Rho GTPase Cdc42. Blanke S, et al. FASEB J, 2006 Apr. PMID 16581976
  4. RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. Nászai M, et al. Elife, 2021 Jun 7. PMID 34096503, Free PMC Article
  5. Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly. Silver JT, et al. J Cell Biol, 2019 Oct 7. PMID 31409654, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. To explore the regulation of GEFmeso protein in vivo, we analyzed the Rho GTPase Cysts, the Drosophila orthologue of mammalian p114RhoGEF, GEF-H1, p190RhoGEF, and AKAP-13..
    Title: Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly.
  2. We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development
    Title: Rac1 is a novel interactor of Drosophila guanine nucleotide exchange factor GEFmeso.
  3. The identification and characterization of a DBL-like guanine nucleotide exchange factor (GEF) in Drosophila, called GEFmeso, as a novel binding target of the Ras-like GTPase Ral.
    Title: Novel guanine nucleotide exchange factor GEFmeso of Drosophila melanogaster interacts with Ral and Rho GTPase Cdc42.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Cdc42 protein signal transduction IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
guanine nucleotide exchange factor in mesoderm
Names
CG30115-PE
CG30115-PF
CG30115-PG
GEFmeso-PE
GEFmeso-PF
GEFmeso-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18554119..18611777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176223.4 → NP_788403.2  guanine nucleotide exchange factor in mesoderm, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788403.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBA1
    Conserved Domains (2) summary
    cd13243
    Location:694 → 839
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:548 → 713
    RhoGEF; RhoGEF domain

  2. NM_001274146.2 → NP_001261075.1  guanine nucleotide exchange factor in mesoderm, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261075.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFB7
    Conserved Domains (2) summary
    cd13243
    Location:694 → 839
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:548 → 713
    RhoGEF; RhoGEF domain

  3. NM_137499.3 → NP_611343.4  guanine nucleotide exchange factor in mesoderm, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611343.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DN64, Q8MSP7
    Conserved Domains (2) summary
    cd13243
    Location:382 → 527
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:236 → 401
    RhoGEF; RhoGEF domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFB7 A0A0B4KFB7
A1ZBA1 A1ZBA1
B3DN64 B3DN64
Q8MSP7 Q8MSP7
Q961L9 Q961L9

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