U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GstE11 Glutathione S transferase E11 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37128, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
GstE11provided by FlyBase
Official Full Name
Glutathione S transferase E11provided by FlyBase
Primary source
FLYBASE:FBgn0034354
Locus tag
Dmel_CG5224
See related
AllianceGenome:FB:FBgn0034354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg5224; CG5224; Dmel\CG5224; gste11; GSTE11
Summary
Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in adult head; larval muscle system; organism; and trunk mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GstE11 in Genome Data Viewer
Location:
55D1-55D1; 2-86 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18503608..18505025)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14391113..14392530)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Dynein axonemal assembly factor 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphoenolpyruvate carboxykinase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Wongsantichon J, et al. Biosci Rep, 2015 Oct 20. PMID 26487708, Free PMC Article
  2. Expression Patterns of Drosophila Melanogaster Glutathione Transferases. Gonis E, et al. Insects, 2022 Jul 7. PMID 35886788, Free PMC Article
  3. Evolutionary and structural analyses of GDAP1, involved in Charcot-Marie-Tooth disease, characterize a novel class of glutathione transferase-related genes. Marco A, et al. Mol Biol Evol, 2004 Jan. PMID 14595091
  4. Microarray analysis of juvenile hormone response in Drosophila melanogaster S2 cells. Willis DK, et al. J Insect Sci, 2010. PMID 20672983, Free PMC Article
  5. A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster. Saisawang C, et al. Biochem J, 2012 Feb 15. PMID 22082028

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glutathione S transferase E11
Names
CG5224-PA
CG5224-PB
GstE11-PA
GstE11-PB
NP_001286575.1
NP_611339.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18503608..18505025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299646.1 → NP_001286575.1  glutathione S transferase E11, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286575.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVZ8
    Conserved Domains (3) summary
    cd03177
    Location:94 → 211
    GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
    COG0625
    Location:5 → 198
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03045
    Location:5 → 78
    GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...

  2. NM_137495.3 → NP_611339.1  glutathione S transferase E11, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611339.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVZ8
    Related
    FBpp0085876
    Conserved Domains (3) summary
    cd03177
    Location:94 → 211
    GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
    COG0625
    Location:5 → 198
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03045
    Location:5 → 78
    GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JVZ8 Q7JVZ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools