Dp1 Dodeca-satellite-binding protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dp1provided by FlyBase
Official Full Name: Dodeca-satellite-binding protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0027835
Locus tag: Dmel_CG5170
See related: AllianceGenome:FB:FBgn0027835
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.516; anon-WO0172774.168; BcDNA:LD21383; BcDNA:LD21677; CG5170; ddp1; DDP1; Dmel\CG5170; DP1
Summary: Enables mRNA 3'-UTR binding activity; satellite DNA binding activity; and single-stranded DNA binding activity. Involved in chromosome condensation; chromosome segregation; and regulation of gene expression. Located in heterochromatin; nucleus; and polytene chromosome chromocenter. Part of ribonucleoprotein complex. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and gut section. Used to study prostate cancer. Orthologous to human HDLBP (high density lipoprotein binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 55C8-55C8; 2-85 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18412027..18421124)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14299532..14308629)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that DDP1 vastly localises to the cytoplasm, being largely excluded from the nucleus, and preferentially associates to RER and co-purifies with several ribosomal proteins.
Title: Drosophila vigilin, DDP1, localises to the cytoplasm and associates to the rough endoplasmic reticulum.
Three proteins (DDP1, Hrp48, and poly(A)-binding protein) are components of the HDE-binding complex and function in translational enhancement
Title: A multiprotein complex that mediates translational enhancement in Drosophila.
DDP1 binds single-stranded nucleic acids with high affinity and contributes to the structural and functional properties of heterochromatin.
Title: Drosophila DDP1, a multi-KH-domain protein, contributes to centromeric silencing and chromosome segregation.
Mutation or depletion of the Drosophila Vigilin, DDP1, leads to altered nuclear morphology and defects in heterochromatin and chromosome segregation.
Title: Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables satellite DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome chromocenter	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Dodeca-satellite-binding protein 1

Names: CG5170-PA; CG5170-PB; CG5170-PD; CG5170-PE; CG5170-PF; CG5170-PG; CG5170-PH; Dp1-PA; Dp1-PB; Dp1-PD; Dp1-PE; Dp1-PF; Dp1-PG; Dp1-PH; dodeca satellite binding protein 1; dodeca-satellite protein 1; dodeca-satellite-binding protein 1; drosophila dodeca-satellite-binding protein 1; vigilin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

18412027..18421124

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206163.2 → NP_995885.1 Dodeca-satellite-binding protein 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995885.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN75, Q9U982

Conserved Domains (1) summary

cd02394
Location:598 → 659

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
NM_166280.2 → NP_725785.1 Dodeca-satellite-binding protein 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725785.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN75, Q9U982

Related

FBpp0085860

Conserved Domains (1) summary

cd02394
Location:598 → 659

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
NM_206164.2 → NP_995886.1 Dodeca-satellite-binding protein 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995886.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN75, Q9U982

Conserved Domains (1) summary

cd02394
Location:598 → 659

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
NM_166282.2 → NP_725787.1 Dodeca-satellite-binding protein 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725787.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN75, Q9U982

Related

FBpp0085861

Conserved Domains (1) summary

cd02394
Location:598 → 659

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
NM_166281.2 → NP_725786.1 Dodeca-satellite-binding protein 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725786.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN75, Q9U982

Related

FBpp0085862

Conserved Domains (1) summary

cd02394
Location:598 → 659

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
NM_001299644.1 → NP_001286573.1 Dodeca-satellite-binding protein 1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286573.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN75, Q9U982

Conserved Domains (1) summary

cd02394
Location:598 → 659

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
NM_079057.3 → NP_523781.2 Dodeca-satellite-binding protein 1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523781.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN75, Q9U982

Related

FBpp0309290

Conserved Domains (1) summary

cd02394
Location:598 → 659

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...