fj four-jointed [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fjprovided by FlyBase
Official Full Name: four-jointedprovided by FlyBase
Primary source: FLYBASE:FBgn0000658
Locus tag: Dmel_CG10917
See related: AllianceGenome:FB:FBgn0000658
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10917; Dmel\CG10917; Fj; FJ; Fjx1
Summary: Enables Wnt-protein binding activity and protein serine/threonine kinase activity. Involved in several processes, including imaginal disc growth; imaginal disc-derived appendage morphogenesis; and regulation of tube length, open tracheal system. Located in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; epithelium; head epidermis primordium; imaginal disc; and organism subdivision. Used to study obesity. Orthologous to human FJX1 (four-jointed box kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 55C1-55C1; 2-85 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18232761..18236311)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14120266..14123816)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings suggest that Fat and the Hippo pathway control four-jointed expression independently of each other and none of the transcription factors known to function downstream of the Hippo pathway are required to regulate four-jointed expression through the 1.2kb element.
Title: Fat regulates expression of four-jointed reporters in vivo through a 20 bp element independently of the Hippo pathway.
Four-jointed acts both on Fat to promote its binding to Dachsous and on Dachsous to inhibit its binding to Fat, with a bias towards a stronger effect on Fat
Title: Cellular interpretation of the long-range gradient of Four-jointed activity in the Drosophila wing.
The gradient of Fj expression, phosphorylation of Ft by Fj and sub-cellular distal accumulation of Ds are three critical elements required for generating sub-cellular asymmetry of Ft-Ds heterodimer.
Title: Mathematical modeling of sub-cellular asymmetry of fat-dachsous heterodimer for generation of planar cell polarity.
Complementary expression of Ds and Fj results in biased Ft and Ds protein distribution across cells, with Ft and Ds accumulating on opposite edges. Asymmetries in protein distribution are transmitted to neighboring cells.
Title: Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous.
study shows how the Fat/Dachsous/Four-jointed planar cell polarity pathway controls morphogenesis
Title: Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway.
effects on wing size and planar polarity by phosphorylating fat (ft) and dachsous (ds) activity
Title: Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat.
modulates fat:daschsous binding and polarization activity via phosphorylation site
Title: Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed.
results indicate that Four-jointed regulates Fat signaling by phosphorylating cadherin domains of Fat and Dachsous as they transit through the Golgi
Title: Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains.
role in signaling interactions that regulate growth and patterning of the proximal wing
Title: Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling.
The gradient of Fj and Ds expression provide partially redundant positional information essential for specifying the polarization. axis
Title: Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell signaling	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell-cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of imaginal disc-derived wing hair orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of ommatidial planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: four-jointed

Names: CG10917-PA; fj-PA; four jointed

NP_477483.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

18232761..18236311

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058135.4 → NP_477483.1 four-jointed [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477483.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54360, Q24176, Q8SZ37, Q9V8E3

Related

FBpp0085933

Conserved Domains (1) summary

cd10468
Location:255 → 583

Four-jointed-like_C; C-terminal kinase domain of Drosophila Four-jointed (Fj), mouse Fjx1, and related proteins