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Ubc10 Ubiquitin conjugating enzyme 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37035, updated on 9-Dec-2024

Summary

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Official Symbol
Ubc10provided by FlyBase
Official Full Name
Ubiquitin conjugating enzyme 10provided by FlyBase
Primary source
FLYBASE:FBgn0026316
Locus tag
Dmel_CG5788
See related
AllianceGenome:FB:FBgn0026316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5788; Dmel\CG5788; EG:52C10.4; ubc; ubcD10; UbcD10
Summary
Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in protein linear polyubiquitination. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to several human genes including UBE2L3 (ubiquitin conjugating enzyme E2 L3) and UBE2L5 (ubiquitin conjugating enzyme E2 L5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ubc10 in Genome Data Viewer
Location:
54E9-54E9; 2-84 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17788412..17789410, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13675917..13676915, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fab1 kinase Neighboring gene mir-31a stem loop Neighboring gene adrift Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45270 Neighboring gene Double hit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. adrift, a novel bnl-induced Drosophila gene, required for tracheal pathfinding into the CNS. Englund C, et al. Development, 1999 Apr. PMID 10068643
  2. Linear ubiquitination by LUBEL has a role in Drosophila heat stress response. Asaoka T, et al. EMBO Rep, 2016 Nov. PMID 27702987, Free PMC Article
  3. Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms. Tan KL, et al. Dev Cell, 2018 Apr 23. PMID 29689197, Free PMC Article
  4. Occurrence of a putative SCF ubiquitin ligase complex in Drosophila. Bocca SN, et al. Biochem Biophys Res Commun, 2001 Aug 17. PMID 11500045
  5. The Drosophila SET domain encoding gene dEset is essential for proper development. Stabell M, et al. Hereditas, 2006 Dec. PMID 17362353

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein linear polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin conjugating enzyme 10
Names
CG5788-PA
Ubc10-PA
NP_477414.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17788412..17789410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058066.4 → NP_477414.1  ubiquitin conjugating enzyme 10 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477414.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K738
    Related
    FBpp0088522
    Conserved Domains (1) summary
    pfam00179
    Location:6 → 144
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K738.1 Q7K738

Gene LinkOut

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