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Vps50 Vacuolar protein sorting 50 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37021, updated on 9-Dec-2024

Summary

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Official Symbol
Vps50provided by FlyBase
Official Full Name
Vacuolar protein sorting 50provided by FlyBase
Primary source
FLYBASE:FBgn0034271
Locus tag
Dmel_CG4996
See related
AllianceGenome:FB:FBgn0034271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4996; Dmel\CG4996; Vps54L
Summary
Predicted to enable SNARE binding activity. Predicted to be involved in endocytic recycling. Located in endosome. Part of GARP complex. Orthologous to human VPS50 (VPS50 subunit of EARP/GARPII complex). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Vps50 in Genome Data Viewer
Location:
54E5-54E7; 2-84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17739901..17743969)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13627406..13631474)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hyccin Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class A Neighboring gene Ionotropic receptor 54a Neighboring gene subito Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling. O'Brien CE, et al. J Cell Biol, 2023 Jan 2. PMID 36239632, Free PMC Article
  2. Using the P[wHy] hybrid transposable element to disrupt genes in region 54D-55B in Drosophila melanogaster. Mohr SE, et al. Genetics, 2002 Sep. PMID 12242231, Free PMC Article
  3. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
  4. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
  5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde transport, endosome to Golgi IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of EARP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EARP complex IEA
Inferred from Electronic Annotation
more info
  
part_of GARP complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
vacuolar protein sorting 50
Names
CG4996-PA
Vps50-PA
vacuolar protein sorting 54L

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17739901..17743969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137414.3 → NP_611258.2  vacuolar protein sorting 50 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611258.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAY8, Q960B0
    Related
    FBpp0086024
    Conserved Domains (2) summary
    pfam10474
    Location:704 → 932
    DUF2451; Protein of unknown function C-terminus (DUF2451)
    pfam10475
    Location:75 → 362
    DUF2450; Protein of unknown function N-terminal domain (DUF2450)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZAY8 A1ZAY8
Q960B0 Q960B0

Gene LinkOut

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