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Dlish Dachs ligand with SH3s [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37014, updated on 9-Dec-2024

Summary

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Official Symbol
Dlishprovided by FlyBase
Official Full Name
Dachs ligand with SH3sprovided by FlyBase
Primary source
FLYBASE:FBgn0034264
Locus tag
Dmel_CG10933
See related
AllianceGenome:FB:FBgn0034264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10933; dlish; Dmel\CG10933; vam; Vam
Summary
Enables cadherin binding activity. Involved in several processes, including establishment of epithelial cell planar polarity; negative regulation of hippo signaling; and protein localization involved in establishment of planar polarity. Located in apical cortex; apicolateral plasma membrane; and subapical part of cell. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Dlish in Genome Data Viewer
Location:
54E2-54E2; 2-84 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17723309..17725056)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13610814..13612561)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene U snoRNA host gene 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 16 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hyccin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamics and stage-specificity of between-population gene expression divergence in the Drosophila melanogaster larval fat body. Glaser-Schmitt A, et al. PLoS Genet, 2023 Apr. PMID 37099612, Free PMC Article
  2. Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway. Fulford AD, et al. J Cell Biol, 2023 May 1. PMID 37071483, Free PMC Article
  3. Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins. Gridnev A, et al. Front Cell Dev Biol, 2022. PMID 35372364, Free PMC Article
  4. Early girl is a novel component of the Fat signaling pathway. Misra JR, et al. PLoS Genet, 2019 Jan. PMID 30699121, Free PMC Article
  5. Fat-regulated adaptor protein Dlish binds the growth suppressor Expanded and controls its stability and ubiquitination. Wang X, et al. Proc Natl Acad Sci U S A, 2019 Jan 22. PMID 30606799, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cadherin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of epithelial cell planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization involved in establishment of planar polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization involved in establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in subapical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dachs ligand with SH3s
Names
CG10933-PA
Dlish-PA
vamana

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17723309..17725056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137407.3 → NP_611251.2  dachs ligand with SH3s [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611251.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZAY1
    UniProtKB/TrEMBL
    Q8IGN9
    Related
    FBpp0086020
    Conserved Domains (2) summary
    cd00174
    Location:61 → 111
    SH3; Src Homology 3 domain superfamily
    smart00326
    Location:184 → 238
    SH3; Src homology 3 domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZAY1.1 A1ZAY1
Q8IGN9 Q8IGN9

Gene LinkOut

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