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CCHa1-R CCHamide-1 receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37004, updated on 9-Dec-2024

Summary

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Official Symbol
CCHa1-Rprovided by FlyBase
Official Full Name
CCHamide-1 receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0050106
Locus tag
Dmel_CG30106
See related
AllianceGenome:FB:FBgn0050106
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CCHa1r; CCHa1R; CCHamide-1 R; CCHamide1r; CG14484; CG18192; CG30106; Dmel\CG30106
Summary
Enables allatostatin receptor activity and neuropeptide receptor activity. Involved in neuropeptide signaling pathway. Located in plasma membrane. Is expressed in adult brain; adult mushroom body; larval VUM motor neurons; neurosecretory neurons; and ventral midline of embryo. Orthologous to human BRS3 (bombesin receptor subtype 3); GRPR (gastrin releasing peptide receptor); and NMBR (neuromedin B receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CCHa1-R in Genome Data Viewer
Location:
54D3-54D4; 2-83 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17646848..17665068, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13534353..13552573, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene rhino Neighboring gene Oxpecker Neighboring gene eukaryotic translation initiation factor 3 subunit c Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental emergence of sleep rhythms enables long-term memory in Drosophila. Poe AR, et al. Sci Adv, 2023 Sep 8. PMID 37683005, Free PMC Article
  2. Expression patterns of the Drosophila neuropeptide CCHamide-2 and its receptor may suggest hormonal signaling from the gut to the brain. Li S, et al. PLoS One, 2013. PMID 24098432, Free PMC Article
  3. The Drosophila genes CG14593 and CG30106 code for G-protein-coupled receptors specifically activated by the neuropeptides CCHamide-1 and CCHamide-2. Hansen KK, et al. Biochem Biophys Res Commun, 2011 Jan 7. PMID 21110953
  4. The CCHamide 1 receptor modulates sensory perception and olfactory behavior in starved Drosophila. Farhan A, et al. Sci Rep, 2013 Sep 26. PMID 24067446, Free PMC Article
  5. The CCHamide1 Neuropeptide Expressed in the Anterior Dorsal Neuron 1 Conveys a Circadian Signal to the Ventral Lateral Neurons in Drosophila melanogaster. Fujiwara Y, et al. Front Physiol, 2018. PMID 30246807, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The CCHamide-1 receptor is another important factor governing starvation-induced olfactory modifications.
    Title: The CCHamide 1 receptor modulates sensory perception and olfactory behavior in starved Drosophila.
  2. G-protein-coupled receptors coded for by genes CG14593 and CG30106 that are selectively activated by Drosophila CCH-amide-1 and CCH-amide-2, respectively, were cloned.
    Title: The Drosophila genes CG14593 and CG30106 code for G-protein-coupled receptors specifically activated by the neuropeptides CCHamide-1 and CCHamide-2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables allatostatin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables allatostatin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide receptor activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CCHamide-1 receptor
Names
ASB-receptor
CCHa1-R-PA
CG30106-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17646848..17665068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137397.3 → NP_611241.2  CCHamide-1 receptor [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611241.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZAX0
    Conserved Domains (2) summary
    pfam00001
    Location:98 → 364
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:88 → 188
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZAX0.2 A1ZAX0

Gene LinkOut

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