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Ns2 Nucleostemin 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36989, updated on 4-Jan-2025

Summary

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Official Symbol
Ns2provided by FlyBase
Official Full Name
Nucleostemin 2provided by FlyBase
Primary source
FLYBASE:FBgn0034243
Locus tag
Dmel_CG6501
See related
AllianceGenome:FB:FBgn0034243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6501; Dmel\CG6501; dmNS2; Ngp; Ngp1; ns2; NS2
Summary
Enables GTPase activity. Involved in compound eye morphogenesis and ribosomal large subunit export from nucleus. Located in nucleolus. Colocalizes with nucleoplasm. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and larval muscle cell. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ns2 in Genome Data Viewer
Location:
54C8-54C9; 2-83 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17565779..17568456, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13453284..13455961, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein at 54D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Plenty of SH3s Neighboring gene Ubiquinol-cytochrome c reductase 6.4 kDa subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila GTPase nucleostemin 2 changes cellular distribution during larval development and the GTP-binding motif is essential to nucleoplasmic localization. Matsuo E, et al. Biosci Biotechnol Biochem, 2011. PMID 21821926
  2. Drosophila nucleostemin 2 proved essential for early eye development and cell survival. Matsuo E, et al. Biosci Biotechnol Biochem, 2010. PMID 20944412
  3. Knockdown of the Drosophila GTPase nucleostemin 1 impairs large ribosomal subunit biogenesis, cell growth, and midgut precursor cell maintenance. Rosby R, et al. Mol Biol Cell, 2009 Oct. PMID 19710426, Free PMC Article
  4. Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila. Hartl TA, et al. Genetics, 2013 May. PMID 23436180, Free PMC Article
  5. Loss of Drosophila nucleostemin 2 (NS2) blocks nucleolar release of the 60S subunit leading to ribosome stress. Wang Y, et al. Chromosoma, 2017 Jun. PMID 27150106

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nucleolar proteins NS1 and NS2 have similar but non-overlapping roles in the final maturation or nucleolar release of 60S ribosomal subunits.
    Title: Loss of Drosophila nucleostemin 2 (NS2) blocks nucleolar release of the 60S subunit leading to ribosome stress.
  2. Drosophila GTPase nucleostemin 2 changes cellular distribution during larval development and the GTP-binding motif is essential to nucleoplasmic localization.
    Title: Drosophila GTPase nucleostemin 2 changes cellular distribution during larval development and the GTP-binding motif is essential to nucleoplasmic localization.
  3. Drosophila nucleostemin 2 (ns2) plays a significant role in early eye development and is essential for cell survival in vivo
    Title: Drosophila nucleostemin 2 proved essential for early eye development and cell survival.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleostemin 2
Names
CG6501-PA
Ns2-PA
nucleostemin ortholog 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17565779..17568456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137388.4 → NP_611232.1  nucleostemin 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611232.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JXU4
    Related
    FBpp0086063
    Conserved Domains (3) summary
    cd01858
    Location:214 → 370
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:206 → 485
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08153
    Location:50 → 179
    NGP1NT; NGP1NT (NUC091) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JXU4 Q7JXU4

Gene LinkOut

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