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insb insensible [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36967, updated on 9-Dec-2024

Summary

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Official Symbol
insbprovided by FlyBase
Official Full Name
insensibleprovided by FlyBase
Primary source
FLYBASE:FBgn0034224
Locus tag
Dmel_CG6520
See related
AllianceGenome:FB:FBgn0034224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6520; Dmel\CG6520
Summary
Involved in negative regulation of Notch signaling pathway. Located in nucleus. Is expressed in mesonotum. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See insb in Genome Data Viewer
Location:
54B16-54B16; 2-82 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17475214..17476272, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13362719..13363777, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Testin Neighboring gene quaking related 54B Neighboring gene uncharacterized protein Neighboring gene veil Neighboring gene Ecto-5'-nucleotidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A nonneural miRNA cluster mediates hearing via repression of two neural targets. Zhang B, et al. Genes Dev, 2023 Dec 26. PMID 38110249, Free PMC Article
  2. Insensible is a novel nuclear inhibitor of Notch activity in Drosophila. Coumailleau F, et al. PLoS One, 2014. PMID 24902027, Free PMC Article
  3. Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors during Drosophila asymmetric neural stem cell division. Komori H, et al. Genes Dev, 2018 Dec 1. PMID 30463902, Free PMC Article
  4. miRNA suppression of a Notch repressor directs non-neuronal fate in Drosophila mechanosensory organs. Kavaler J, et al. J Cell Biol, 2018 Feb 5. PMID 29196461, Free PMC Article
  5. Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes. Rives-Quinto N, et al. Elife, 2020 Nov 26. PMID 33241994, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
insensible
Names
CG6520-PA
CG6520-PB
insb-PA
insb-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17475214..17476272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299602.1 → NP_001286531.1  insensible, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286531.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZ51

  2. NM_137372.4 → NP_611216.1  insensible, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611216.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZ51
    Related
    FBpp0086109
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JZ51 Q7JZ51

Gene LinkOut

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