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qkr54B quaking related 54B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36966, updated on 9-Dec-2024

Summary

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Official Symbol
qkr54Bprovided by FlyBase
Official Full Name
quaking related 54Bprovided by FlyBase
Primary source
FLYBASE:FBgn0022987
Locus tag
Dmel_CG4816
See related
AllianceGenome:FB:FBgn0022987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4816; Dmel\CG4816; p62GAP; Qkr54B; QKR54B; qrk54B; Qrk54B; SAM; Sam50; SAM50
Summary
Enables RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasm. Is expressed in organism and ovary. Orthologous to several human genes including KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See qkr54B in Genome Data Viewer
Location:
54B16-54B16; 2-82 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17469624..17475129)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13357129..13362634)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Testin Neighboring gene insensible Neighboring gene uncharacterized protein Neighboring gene veil

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional and phylogenetic properties of the pore-forming beta-barrel transporters of the Omp85 family. Bredemeier R, et al. J Biol Chem, 2007 Jan 19. PMID 17088246
  2. The identification of two Drosophila K homology domain proteins. Kep1 and SAM are members of the Sam68 family of GSG domain proteins. Di Fruscio M, et al. J Biol Chem, 1998 Nov 13. PMID 9804767
  3. Kep1 interacts genetically with dredd/caspase-8, and kep1 mutants alter the balance of dredd isoforms. Di Fruscio M, et al. Proc Natl Acad Sci U S A, 2003 Feb 18. PMID 12563030, Free PMC Article
  4. A family of Drosophila genes encoding quaking-related maxi-KH domains. Fyrberg C, et al. Biochem Genet, 1998 Feb. PMID 9562906
  5. Insensible is a novel nuclear inhibitor of Notch activity in Drosophila. Coumailleau F, et al. PLoS One, 2014. PMID 24902027, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
quaking related 54B
Names
CG4816-PA
CG4816-PB
CG4816-PD
CG4816-PE
qkr54B-PA
qkr54B-PB
qkr54B-PD
qkr54B-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17469624..17475129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274121.1 → NP_001261050.1  quaking related 54B, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261050.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFT9
    Conserved Domains (2) summary
    cd02395
    Location:122 → 237
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:68 → 117
    Qua1; Qua1 domain

  2. NM_166231.3 → NP_725680.2  quaking related 54B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725680.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAT7, O44433, Q7KNS5
    Conserved Domains (2) summary
    cd02395
    Location:122 → 237
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:68 → 117
    Qua1; Qua1 domain

  3. NM_166230.3 → NP_725679.1  quaking related 54B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725679.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAT7, O44433, Q7KNS5
    Related
    FBpp0086079
    Conserved Domains (2) summary
    cd02395
    Location:122 → 237
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:68 → 117
    Qua1; Qua1 domain

  4. NM_079048.4 → NP_523772.1  quaking related 54B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAT7, O44433, Q7KNS5
    Related
    FBpp0086081
    Conserved Domains (2) summary
    cd02395
    Location:122 → 237
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:68 → 117
    Qua1; Qua1 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFT9 A0A0B4KFT9
O44433 O44433
Q7KNS5 Q7KNS5

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