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robl roadblock [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36963, updated on 4-Jan-2025

Summary

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Official Symbol
roblprovided by FlyBase
Official Full Name
roadblockprovided by FlyBase
Primary source
FLYBASE:FBgn0024196
Locus tag
Dmel_CG10751
See related
AllianceGenome:FB:FBgn0024196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10751; DLC; Dmel\CG10751; l(2)k10408; LC7; Roadblock; roblk
Summary
Enables dynein intermediate chain binding activity. Involved in dendrite morphogenesis; microtubule-based movement; and mushroom body development. Part of axonemal dynein complex and cytoplasmic dynein complex. Orthologous to several human genes including DYNLRB2 (dynein light chain roadblock-type 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See robl in Genome Data Viewer
Location:
54B16-54B16; 2-82 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17456472..17457129)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13343977..13344634)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene roadblock similar 54B Neighboring gene uncharacterized protein Neighboring gene Testin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatial and temporal characteristics of normal and perturbed vesicle transport. Iacobucci GJ, et al. PLoS One, 2014. PMID 24878565, Free PMC Article
  2. Presenilin influences glycogen synthase kinase-3 β (GSK-3β) for kinesin-1 and dynein function during axonal transport. Dolma K, et al. Hum Mol Genet, 2014 Mar 1. PMID 24105467
  3. The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly. Hall J, et al. J Biol Chem, 2010 Jul 16. PMID 20472935, Free PMC Article
  4. A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis. Reuter JE, et al. Development, 2003 Mar. PMID 12571111
  5. Light chain-dependent self-association of dynein intermediate chain. Nyarko A, et al. J Biol Chem, 2011 Jan 14. PMID 20974845, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein intermediate chain binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of axonemal dynein complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
roadblock
Names
CG10751-PA
dynein light chain
dynein light chain LC7
dynein, light chain, roadblock-type 2
robl-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17456472..17457129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079047.4 → NP_523771.1  roadblock [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523771.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMS3
    Related
    FBpp0086076
    Conserved Domains (1) summary
    pfam03259
    Location:4 → 94
    Robl_LC7; Roadblock/LC7 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KMS3 Q7KMS3

Gene LinkOut

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