Lhr Lethal hybrid rescue [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lhrprovided by FlyBase
Official Full Name: Lethal hybrid rescueprovided by FlyBase
Primary source: FLYBASE:FBgn0034217
Locus tag: Dmel_CG18468
See related: AllianceGenome:FB:FBgn0034217
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18468; Dmel\CG18468; HP3; LHR; LHR[[mel]]; mel-Lhr
Summary: Predicted to enable DNA binding activity. Involved in mitotic sister chromatid segregation; telomere maintenance; and transposable element silencing by heterochromatin formation. Located in chromocenter; chromosome, telomeric repeat region; and pericentric heterochromatin. Is expressed in organism and spermatozoon. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 54B7-54B7; 2-82 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (17431032..17432219)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (13318537..13319724)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila.
Title: The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila.
We conclude that there is no evidence for a centromeric function of Hmr and Lhr within D. melanogaster nor for a centromere defect causing hybrid lethality. Instead, we find that Hmr and Lhr are required in D. melanogaster for detachment of sister chromatids during anaphase.
Title: The Hybrid Incompatibility Genes Lhr and Hmr Are Required for Sister Chromatid Detachment During Anaphase but Not for Centromere Function.
Using RNA-Seq analyses we discovered that Hmr and Lhr are required to repress transcripts from satellite DNAs and many families of transposable elements (TEs).
Title: The Hmr and Lhr hybrid incompatibility genes suppress a broad range of heterochromatic repeats.
Results are consistent with the allelic asymmetry model of the Lhr gene expression in the hybrid.
Title: Allelic asymmetry of the Lethal hybrid rescue (Lhr) gene expression in the hybrid between Drosophila melanogaster and D. simulans: confirmation by using genetic variations of D. melanogaster.
LHR orthologs interact with HP1 and HP6, and can localize to heterochromatin when expressed in D. melanogaster.
Title: Functional conservation of the Drosophila hybrid incompatibility gene Lhr.
findings show Lhr has functionally diverged in D. simulans & interacts with Hybrid male rescue, which has functionally diverged in D. melanogaster, to cause lethality in F1 hybrid males; LHR has diverged in these species consistent with positive selection
Title: Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing by heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric repeat region	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed