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Mtap Methylthioadenosine phosphorylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36955, updated on 9-Dec-2024

Summary

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Official Symbol
Mtapprovided by FlyBase
Official Full Name
Methylthioadenosine phosphorylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0034215
Locus tag
Dmel_CG4802
See related
AllianceGenome:FB:FBgn0034215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4802; Dmel\CG4802; MTAP
Summary
Predicted to enable S-methyl-5-thioadenosine phosphorylase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be active in cytosol. Is expressed in adult head; fat body primordium; and visceral mesoderm. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Mtap in Genome Data Viewer
Location:
54B7-54B7; 2-82 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17427795..17429315)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13315300..13316820)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene connector enhancer of ksr Neighboring gene lethal (2) k01209 Neighboring gene uncharacterized protein Neighboring gene Brahma associated protein 55kD Neighboring gene Lethal hybrid rescue Neighboring gene Egg-derived tyrosine phosphatase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis. Williamson RE, et al. Am J Med Genet A, 2007 Jul 15. PMID 17534888
  2. Unraveling the protective effect of a Drosophila phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics. Reumer A, et al. Dev Comp Immunol, 2009 Nov. PMID 19545586
  3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
  4. Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Orian A, et al. Genes Dev, 2003 May 1. PMID 12695332, Free PMC Article
  5. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables S-methyl-5-thioadenosine phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-methyl-5-thioadenosine phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-methionine salvage from methylthioadenosine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methylthioadenosine phosphorylase
Names
CG4802-PA
CG4802-PB
CG4802-PC
Mtap-PA
Mtap-PB
Mtap-PC
methylthioadenosine phosphorylase ortholog
NP_001261049.1
NP_001286525.1
NP_611208.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17427795..17429315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299596.1 → NP_001286525.1  methylthioadenosine phosphorylase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286525.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V813
    UniProtKB/TrEMBL
    A0A0B4LFH0
    Conserved Domains (2) summary
    COG0005
    Location:12 → 264
    XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
    cl00303
    Location:17 → 263
    PNP_UDP_1; Phosphorylase superfamily

  2. NM_137364.4 → NP_611208.1  methylthioadenosine phosphorylase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611208.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V813
    UniProtKB/TrEMBL
    A0A0B4LFH0
    Related
    FBpp0086072
    Conserved Domains (2) summary
    COG0005
    Location:12 → 264
    XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
    cl00303
    Location:17 → 263
    PNP_UDP_1; Phosphorylase superfamily

  3. NM_001274120.2 → NP_001261049.1  methylthioadenosine phosphorylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261049.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG54
    Conserved Domains (2) summary
    COG0005
    Location:12 → 264
    XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
    cl00303
    Location:17 → 263
    PNP_UDP_1; Phosphorylase superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KG54 A0A0B4KG54
A0A0B4LFH0 A0A0B4LFH0
Q9V813.1 Q9V813

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