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AsnRS-m Asparaginyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36909, updated on 4-Jan-2025

Summary

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Official Symbol
AsnRS-mprovided by FlyBase
Official Full Name
Asparaginyl-tRNA synthetase, mitochondrialprovided by FlyBase
Primary source
FLYBASE:FBgn0034177
Locus tag
Dmel_CG6796
See related
AllianceGenome:FB:FBgn0034177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6796; Dmel\CG6796
Summary
Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in mitochondrial asparaginyl-tRNA aminoacylation. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic epipharynx; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See AsnRS-m in Genome Data Viewer
Location:
53E4-53E4; 2-81 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17001994..17003599)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12889499..12891104)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ste24b prenyl protease type I Neighboring gene prenyl protease type I Neighboring gene Nuclear inhibitor of Protein phosphatase 1 Neighboring gene uncharacterized protein Neighboring gene Eps15 homology domain containing protein-binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster. Vrailas-Mortimer AD, et al. MicroPubl Biol, 2021 Jan 18. PMID 33474526, Free PMC Article
  2. Population genomics of Wolbachia and mtDNA in Drosophila simulans from California. Signor S. Sci Rep, 2017 Oct 17. PMID 29042606, Free PMC Article
  3. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
  4. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
  5. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables asparagine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparagine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables asparagine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables asparagine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in asparaginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparaginyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in asparaginyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitochondrial asparaginyl-tRNA aminoacylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Asparaginyl-tRNA synthetase, mitochondrial
Names
AsnRS-m-PA
CG6796-PA
NP_611176.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17001994..17003599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137332.3 → NP_611176.1  Asparaginyl-tRNA synthetase, mitochondrial [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611176.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZR5
    Related
    FBpp0086205
    Conserved Domains (3) summary
    PRK03932
    Location:13 → 460
    asnC; asparaginyl-tRNA synthetase; Validated
    cd00776
    Location:115 → 456
    AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
    cd04318
    Location:27 → 101
    EcAsnRS_like_N; EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JZR5 Q7JZR5

Gene LinkOut

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