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ste24b ste24b prenyl protease type I [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36907, updated on 9-Dec-2024

Summary

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Official Symbol
ste24bprovided by FlyBase
Official Full Name
ste24b prenyl protease type Iprovided by FlyBase
Primary source
FLYBASE:FBgn0034175
Locus tag
Dmel_CG9001
See related
AllianceGenome:FB:FBgn0034175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9001; Dmel\CG9001; Dmel\Ste24; Dmel\Ste24b
Summary
Predicted to enable metalloendopeptidase activity. Involved in spermatogenesis. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ste24b in Genome Data Viewer
Location:
53E4-53E4; 2-81 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16998610..17000126, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12886115..12887631, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44377 Neighboring gene Calbindin 53E Neighboring gene uncharacterized protein Neighboring gene ste24c prenyl protease type I Neighboring gene prenyl protease type I Neighboring gene Asparaginyl-tRNA synthetase, mitochondrial Neighboring gene Nuclear inhibitor of Protein phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Type-I prenyl protease function is required in the male germline of Drosophila melanogaster. Adolphsen K, et al. G3 (Bethesda), 2012 Jun. PMID 22690372, Free PMC Article
  2. Population genomics of Wolbachia and mtDNA in Drosophila simulans from California. Signor S. Sci Rep, 2017 Oct 17. PMID 29042606, Free PMC Article
  3. An ABC transporter controls export of a Drosophila germ cell attractant. Ricardo S, et al. Science, 2009 Feb 13. PMID 19213920, Free PMC Article
  4. Selection, recombination and demographic history in Drosophila miranda. Bachtrog D, et al. Genetics, 2006 Dec. PMID 17028331, Free PMC Article
  5. Wun2-mediated integrin recycling promotes apoptotic cell clearance in Drosophila melanogaster. Gao N, et al. Cell Death Differ, 2022 Dec. PMID 35840760, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in CAAX-box protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CAAX-box protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ste24b prenyl protease type I
Names
CG9001-PA
prenyl protease type I
ste24b-PA
NP_611174.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16998610..17000126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137330.1 → NP_611174.1  ste24b prenyl protease type I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611174.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAM7, Q8IHA2
    Related
    FBpp0086208, FBtr0087060
    Conserved Domains (3) summary
    COG0501
    Location:167 → 444
    HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
    pfam01435
    Location:220 → 444
    Peptidase_M48; Peptidase family M48
    pfam16491
    Location:35 → 214
    Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZAM7 A1ZAM7
Q8IHA2 Q8IHA2

Gene LinkOut

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