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rrm2b - ribonucleotide reductase M2 b

Predicted to enable ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Acts upstream of or within DNA damage response and mitochondrial genome maintenance. Located in cytoplasm. Is expressed in several structures, including brain; eye; liver; otic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa