prmt5 protein arginine methyltransferase 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prmt5provided by ZNC
Official Full Name: protein arginine methyltransferase 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-585
See related: Ensembl:ENSDARG00000079605 AllianceGenome:ZFIN:ZDB-GENE-030616-585
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: skb1; wu:fb95f10; zgc:110669; si:zc14a17.2
Summary: Enables histone H4R3 methyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Involved in peptidyl-arginine methylation, to symmetrical-dimethyl arginine. Acts upstream of or within regulation of skeletal muscle fiber development and vasculogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including heart; liver; pleuroperitoneal region; segmental plate; and shield. Orthologous to human PRMT5 (protein arginine methyltransferase 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (38342287..38363017, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (38359959..38380689, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.
Title: Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.
a combinatorial role of PRMT4/CARM1 and PRMT5 for proper myogenesis in zebrafish
Title: The methyltransferases PRMT4/CARM1 and PRMT5 control differentially myogenesis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone H4R3 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone arginine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine omega-N symmetric methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N symmetric methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine omega-N symmetric methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-arginine N-methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-arginine methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-arginine methylation, to symmetrical-dimethyl arginine	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-arginine methylation, to symmetrical-dimethyl arginine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein methylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein arginine N-methyltransferase 5

Names: SKB1 homolog

NP_001007184.2

EC 2.1.1.125

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.