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CG5065 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36860, updated on 4-Jan-2025

Summary

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Official Symbol
CG5065provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034145
Locus tag
Dmel_CG5065
See related
AllianceGenome:FB:FBgn0034145
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5065; FAR1; FAR1/2
Summary
Predicted to enable alcohol-forming long-chain fatty acyl-CoA reductase activity and alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in ether lipid biosynthetic process; long-chain fatty-acyl-CoA metabolic process; and wax biosynthetic process. Predicted to be located in peroxisomal membrane. Predicted to be active in peroxisome. Is expressed in adult head; embryonic/larval foregut; embryonic/larval hindgut; and larval central nervous system. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctate type 4. Orthologous to several human genes including FAR1 (fatty acyl-CoA reductase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG5065 in Genome Data Viewer
Location:
53C11-53C12; 2-80 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16607654..16624894)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12495159..12512399)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Anaplastic lymphoma kinase Neighboring gene gprs Neighboring gene Amylase related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reducing ether lipids improves Drosophila overnutrition-associated pathophysiology phenotypes via a switch from lipid storage to beta-oxidation. Santoro C, et al. Sci Rep, 2022 Jul 29. PMID 35906462, Free PMC Article
  2. The Zic family homologue Odd-paired regulates Alk expression in Drosophila. Mendoza-García P, et al. PLoS Genet, 2017 Apr. PMID 28369060, Free PMC Article
  3. Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo. Lorén CE, et al. Genes Cells, 2001 Jun. PMID 11442633, Free PMC Article
  4. Birth-and-Death Evolution of the Fatty Acyl-CoA Reductase (FAR) Gene Family and Diversification of Cuticular Hydrocarbon Synthesis in Drosophila. Finet C, et al. Genome Biol Evol, 2019 Jun 1. PMID 31076758, Free PMC Article
  5. Gene expression and morphogenesis during the deposition of Drosophila wing cuticle. Adler PN. Fly (Austin), 2017 Jul 3. PMID 28631994, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alcohol-forming long-chain fatty acyl-CoA reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ether lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wax biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in peroxisomal membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5065-PA
CG5065-PB
CG5065-PC
CG5065-PD
CG5065-PE
fatty acyl-CoA reductase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16607654..16624894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137299.4 → NP_611143.1  uncharacterized protein Dmel_CG5065, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611143.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZAI5
    UniProtKB/TrEMBL
    E1JH83
    Related
    FBpp0086254
    Conserved Domains (2) summary
    cd05236
    Location:126 → 445
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:472 → 562
    Sterile; Male sterility protein

  2. NM_001259441.2 → NP_001246370.1  uncharacterized protein Dmel_CG5065, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246370.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZAI5
    UniProtKB/TrEMBL
    E1JH83
    Conserved Domains (2) summary
    cd05236
    Location:126 → 445
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:472 → 562
    Sterile; Male sterility protein

  3. NM_001259442.2 → NP_001246371.1  uncharacterized protein Dmel_CG5065, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246371.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZAI5
    UniProtKB/TrEMBL
    E1JH83
    Conserved Domains (2) summary
    cd05236
    Location:126 → 445
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:472 → 562
    Sterile; Male sterility protein

  4. NM_001169698.3 → NP_001163169.1  uncharacterized protein Dmel_CG5065, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163169.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZAI5
    UniProtKB/TrEMBL
    E1JH83
    Conserved Domains (2) summary
    cd05236
    Location:126 → 445
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:472 → 562
    Sterile; Male sterility protein

  5. NM_001169697.3 → NP_001163168.1  uncharacterized protein Dmel_CG5065, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163168.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZAI5
    UniProtKB/TrEMBL
    E1JH83
    Conserved Domains (2) summary
    cd05236
    Location:126 → 445
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:472 → 562
    Sterile; Male sterility protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZAI5.1 A1ZAI5
E1JH83 E1JH83

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