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Cdk4 - Cyclin-dependent kinase 4

Enables cyclin binding activity. Involved in several processes, including positive regulation of cell growth; positive regulation of signal transduction; and regulation of mitochondrion organization. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including familial melanoma; high grade glioma (multiple); pancreatic carcinoma (multiple); primary autosomal recessive microcephaly 12; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4) and CDK6 (cyclin dependent kinase 6). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to Cdk4

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Species Gene Architecture aa