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epb41l5 erythrocyte membrane protein band 4.1 like 5 [ Danio rerio (zebrafish) ]

Gene ID: 368449, updated on 9-Dec-2024

Summary

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Official Symbol
epb41l5provided by ZNC
Official Full Name
erythrocyte membrane protein band 4.1 like 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-450
See related
Ensembl:ENSDARG00000032324 AllianceGenome:ZFIN:ZDB-GENE-030616-450
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dZ104F18.2; dZ104F18.3; si:dz37o5.2; si:dz104f18.2; si:dz104f18.3
Summary
Predicted to enable cytoskeletal protein binding activity. Acts upstream of or within several processes, including eye morphogenesis; maintenance of epithelial cell apical/basal polarity; and positive regulation of Notch signaling pathway. Located in bicellular tight junction. Part of protein-containing complex. Is expressed in integument; nervous system; and pronephros. Used to study proteinuria. Orthologous to human EPB41L5 (erythrocyte membrane protein band 4.1 like 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See epb41l5 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (28870697..28939210, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (29059948..29128478, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101884827 Neighboring gene receptor activity modifying protein 1 Neighboring gene uncharacterized LOC137490688 Neighboring gene protein tyrosine phosphatase non-receptor type 4a Neighboring gene transmembrane protein 177

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sexually dimorphic gene expression in the brains of mature zebrafish. Santos EM, et al. Comp Biochem Physiol A Mol Integr Physiol, 2008 Mar. PMID 18289901
  2. Molecular and cellular determinants of motor asymmetry in zebrafish. Horstick EJ, et al. Nat Commun, 2020 Mar 3. PMID 32127541, Free PMC Article
  3. Zebrafish mosaic eyes is a novel FERM protein required for retinal lamination and retinal pigmented epithelial tight junction formation. Jensen AM, et al. Curr Biol, 2004 Apr 20. PMID 15084287
  4. Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes. Kramer-Zucker AG, et al. Dev Biol, 2005 Sep 15. PMID 16102746, Free PMC Article
  5. Tissue-specific requirements for specific domains in the FERM protein Moe/Epb4.1l5 during early zebrafish development. Christensen AK, et al. BMC Dev Biol, 2008 Jan 11. PMID 18190700, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epb41l5 interacts with Iqcb1 and regulates ciliary function in zebrafish embryos.
    Title: Epb41l5 interacts with Iqcb1 and regulates ciliary function in zebrafish embryos.
  2. Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.
    Title: Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.
  3. Data suggest that the Crb/Moe complex and Notch play roles in a positive feedback loop to maintain the apicobasal polarity in neuroepithelial cells.
    Title: Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells.
  4. our data provide further evidence that Moe is a negative regulator of rod outer segment size
    Title: Tissue-specific requirements for specific domains in the FERM protein Moe/Epb4.1l5 during early zebrafish development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1548

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dorsal motor nucleus of vagus nerve development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of Notch signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within protein-containing complex localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
band 4.1-like protein 5
Names
moe
mosaic eyes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200089.2 → NP_956383.1  band 4.1-like protein 5

    See identical proteins and their annotated locations for NP_956383.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066560
    UniProtKB/TrEMBL
    Q6NYK4
    Related
    ENSDARP00000092050.4, ENSDART00000101276.6
    Conserved Domains (5) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 331
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    cd14473
    Location:135 → 227
    FERM_B-lobe; FERM domain B-lobe
    pfam08736
    Location:344 → 375
    FA; FERM adjacent (FA)
    pfam09379
    Location:47 → 109
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    28870697..28939210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223331.1 → XP_068079432.1  band 4.1-like protein 5 isoform X7

  2. XM_068223327.1 → XP_068079428.1  band 4.1-like protein 5 isoform X3

    Related
    ENSDARP00000119020.1, ENSDART00000132878.3

  3. XM_068223330.1 → XP_068079431.1  band 4.1-like protein 5 isoform X6

  4. XM_068223328.1 → XP_068079429.1  band 4.1-like protein 5 isoform X4

  5. XM_068223329.1 → XP_068079430.1  band 4.1-like protein 5 isoform X5

  6. XM_068223326.1 → XP_068079427.1  band 4.1-like protein 5 isoform X2

  7. XM_068223324.1 → XP_068079425.1  band 4.1-like protein 5 isoform X1

    Related
    ENSDARP00000092043.5, ENSDART00000101269.5

  8. XM_068223325.1 → XP_068079426.1  band 4.1-like protein 5 isoform X1

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395284.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    154837..217168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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