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cdkn1bb - cyclin dependent kinase inhibitor 1Bb

Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein-folding chaperone binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle; negative regulation of epithelial cell proliferation; and negative regulation of mitotic cell cycle. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in endosome. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including axis; nervous system; pectoral fin; polster; and solid lens vesicle. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

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Species Gene Architecture aa