slc16a1b solute carrier family 16 member 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc16a1bprovided by ZNC
Official Full Name: solute carrier family 16 member 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030515-5
See related: Ensembl:ENSDARG00000068572 AllianceGenome:ZFIN:ZDB-GENE-030515-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MCT1a; cb517; slc16a1; zgc:55682
Summary: Predicted to enable lactate:proton symporter activity. Predicted to be involved in plasma membrane lactate transport. Predicted to act upstream of or within monocarboxylic acid transport and transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including central nervous system; digestive system; liver primordium; musculature system; and neural tube. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (26923613..26961739, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (26904474..26942600, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that monocarboxylate transporters (MCTs1-4) were all found to be expressed in brains of embryos, and were localized in both neurons and astrocyte.
Title: Spatial expression and functional flexibility of monocarboxylate transporter isoforms in the zebrafish brain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lactate:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables monocarboxylic acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monocarboxylic acid transport	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane lactate transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: monocarboxylate transporter 1b

Names: MCT1; monocarboxylate transporter 1a; solute carrier family 16 (monocarboxylate transporter), member 1; solute carrier family 16 (monocarboxylate transporter), member 1b; solute carrier family 16 (monocarboxylic acid transporters), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200085.1 → NP_956379.1 monocarboxylate transporter 1b

See identical proteins and their annotated locations for NP_956379.1

Status: PROVISIONAL

Source sequence(s)

BC048883

UniProtKB/TrEMBL

A0A2R8Q3I0, F6NIZ2, H1ABW1, Q7ZUL1

Related

ENSDARP00000089986.3, ENSDART00000099214.4

Conserved Domains (2) summary

cd06174
Location:20 → 415

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00892
Location:1 → 442

2A0113; monocarboxylate transporter 1