paqr7b progestin and adipoQ receptor family member VII, b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: paqr7bprovided by ZNC
Official Full Name: progestin and adipoQ receptor family member VII, bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030728-2
See related: Ensembl:ENSDARG00000034907 AllianceGenome:ZFIN:ZDB-GENE-030728-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mpra; paqr7
Summary: Enables nuclear steroid receptor activity and steroid binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and steroid hormone receptor signaling pathway. Acts upstream of or within oocyte maturation; response to steroid hormone; and signal transduction. Located in plasma membrane. Is expressed in several structures, including brain; gill; gonad; intestine; and sperm. Orthologous to human PAQR7 (progestin and adipoQ receptor family member 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (34522977..34533191)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (34568947..34584371)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

membrane progestin receptor alpha is the long-sought-after nongenomic progestin receptor that deciphers extracellular non genomic progestin signaling to initiate meiosis resumption in follicle-enclosed zebrafish oocytes
Title: Controls of meiotic signaling by membrane or nuclear progestin receptor in zebrafish follicle-enclosed oocytes.
Expression of mPRalpha and mPRbeta increased as follicles developed; investigators also studied regulation of expression of mPRs by oocyte maturation-inducing hormones (TGF-beta1, activin-A, hCG, or BMP-15).
Title: Regulation of membrane progestin receptors in the zebrafish ovary by gonadotropin, activin, TGF-beta and BMP-15.
progestin receptor mediates a nonclassical action of progestins to induce oocyte maturation in fish
Title: Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes.

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General gene information

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Markers

fj38b07.x1 (e-PCR)
- UniSTS:188497

fj43c10.x1 (e-PCR)
- UniSTS:188551

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables nuclear steroid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear steroid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IBA Inferred from Biological aspect of Ancestor more info
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in response to steroid hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid hormone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: membrane progestin receptor alpha-B

Names: PR alpha; mPR alpha; membrane progestin receptor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.