rybpa RING1 and YY1 binding protein a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rybpaprovided by ZNC
Official Full Name: RING1 and YY1 binding protein aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030424-3
See related: Ensembl:ENSDARG00000037773 AllianceGenome:ZFIN:ZDB-GENE-030424-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rybp; cb337; wu:fi34f03
Summary: Predicted to enable DNA binding activity and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within apoptotic process and positive regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in basal plate midbrain region; central nervous system; and retina. Orthologous to human RYBP (RING1 and YY1 binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (10762577..10786400, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (10827607..10851430, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Yaf2 and Rybp can encode opposing functions in the regulation of apoptosis [yaf2]
Title: Yaf2 inhibits caspase 8-mediated apoptosis and regulates cell survival during zebrafish embryogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RING1 and YY1-binding protein A

Names: DED-associated factor A; death effector domain-associated factor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201317.2 → NP_958474.2 RING1 and YY1-binding protein A

Status: VALIDATED

Source sequence(s)

CT027567, EH571426

UniProtKB/Swiss-Prot

Q7SYB3

UniProtKB/TrEMBL

A0A8M1PEB2, F1R1S9

Related

ENSDARP00000055037.3, ENSDART00000055038.4

Conserved Domains (2) summary

sd00029
Location:23 → 42

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:20 → 43

zf-RanBP; Zn-finger in Ran binding protein and others