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Zc4h2 zinc finger C4H2-type containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 367838, updated on 27-Nov-2024

Summary

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Official Symbol
Zc4h2provided by RGD
Official Full Name
zinc finger C4H2-type containingprovided by RGD
Primary source
RGD:1561708
See related
EnsemblRapid:ENSRNOG00000056735 AllianceGenome:RGD:1561708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561708
Summary
Predicted to be involved in nervous system development and positive regulation of neuron differentiation. Predicted to act upstream of or within noradrenergic neuron development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Predicted to be located in cytoplasm; neuronal cell body; and postsynaptic membrane. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Miles-Carpenter syndrome. Orthologous to human ZC4H2 (zinc finger C4H2-type containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 64.2), Lung (RPKM 31.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zc4h2 in Genome Data Viewer
Location:
Xq22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (64525725..64556037, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (60525706..60546519, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (64887978..64908682, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 12 Neighboring gene ribosomal protein SA, pseudogene 14 Neighboring gene profilin-2-like Neighboring gene glutamic-oxaloacetic transaminase 2, pseudogene 6 Neighboring gene adenylosuccinate lyase, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ZC4H2 mutations are associated with arthrogryposis multiplex congenita and intellectual disability through impairment of central and peripheral synaptic plasticity. Hirata H, et al. Am J Hum Genet, 2013 May 2. PMID 23623388, Free PMC Article
  2. ZC4H2, an XLID gene, is required for the generation of a specific subset of CNS interneurons. May M, et al. Hum Mol Genet, 2015 Sep 1. PMID 26056227, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within noradrenergic neuron development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger C4H2 domain-containing protein
Names
zinc finger, C4H2 domain containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126374.2 → NP_001119846.1  zinc finger C4H2 domain-containing protein

    See identical proteins and their annotated locations for NP_001119846.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6ABD4, B1WC48
    Conserved Domains (1) summary
    pfam10146
    Location:13 → 221
    zf-C4H2; Zinc finger-containing protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    64525725..64556037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280180.1 → XP_063136250.1  zinc finger C4H2 domain-containing protein isoform X1

  2. XM_063280181.1 → XP_063136251.1  zinc finger C4H2 domain-containing protein isoform X2

    UniProtKB/TrEMBL
    B1WC48

  3. XM_063280182.1 → XP_063136252.1  zinc finger C4H2 domain-containing protein isoform X5

  4. XM_039099948.2 → XP_038955876.1  zinc finger C4H2 domain-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABD4
    Related
    ENSRNOP00000072405.2, ENSRNOT00000084107.3
    Conserved Domains (1) summary
    pfam10146
    Location:17 → 224
    zf-C4H2; Zinc finger-containing protein

  5. XM_039099949.2 → XP_038955877.1  zinc finger C4H2 domain-containing protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6ABD4
    Conserved Domains (1) summary
    pfam10146
    Location:1 → 198
    zf-C4H2; Zinc finger-containing protein

  6. XM_039099950.2 → XP_038955878.1  zinc finger C4H2 domain-containing protein isoform X4

    Conserved Domains (1) summary
    pfam10146
    Location:13 → 146
    zf-C4H2; Zinc finger-containing protein
Nucleotide Protein Strain
Heading Accession and Version

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