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casp caspar [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36769, updated on 4-Jan-2025

Summary

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Official Symbol
caspprovided by FlyBase
Official Full Name
casparprovided by FlyBase
Primary source
FLYBASE:FBgn0034068
Locus tag
Dmel_CG8400
See related
AllianceGenome:FB:FBgn0034068
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Casp; CASP; Caspar; CG8400; Dmel\CG8400; FAF1
Summary
Predicted to enable ubiquitin binding activity. Involved in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; negative regulation of peptidoglycan recognition protein signaling pathway; and negative regulation of proteolysis. Located in cytoplasm. Is expressed in organism. Orthologous to human FAF1 (Fas associated factor 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See casp in Genome Data Viewer
Location:
52D14-52D15; 2-76 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16024628..16028161, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11912133..11915666, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rrp42 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SP2353

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caspar SUMOylation regulates Drosophila lifespan. Kaduskar B, et al. MicroPubl Biol, 2020 Aug 2. PMID 32760885, Free PMC Article
  2. Age-dependent dynamics of neuronal VAPB(ALS) inclusions in the adult brain. Thulasidharan A, et al. Neurobiol Dis, 2024 Jun 15. PMID 38679111
  3. SUMO conjugation regulates immune signalling. Hegde S, et al. Fly (Austin), 2020 Mar-Dec. PMID 32777975, Free PMC Article
  4. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
  5. Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease. Tendulkar S, et al. Hum Mol Genet, 2022 Aug 25. PMID 35377453, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
caspar
Names
CG8400-PA
CG8400-PB
CG8400-PC
casp-PA
casp-PB
casp-PC
casper

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16024628..16028161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206126.2 → NP_995848.1  caspar, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995848.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F0JAP4, Q7JUP3
    Conserved Domains (4) summary
    cd01769
    Location:148 → 182
    UBL; Ubiquitin-like domain of UBL
    cd01771
    Location:616 → 695
    Faf1_UBX; Faf1 UBX domain
    cd02990
    Location:392 → 530
    UAS_FAF1; UAS family, FAS-associated factor 1 (FAF1) subfamily; FAF1 contains a UAS domain of unknown function N-terminal to a ubiquitin-associated UBX domain. FAF1 also contains ubiquitin-associated UBA and nuclear targeting domains, N-terminal to the UAS domain. ...
    cd14413
    Location:12 → 44
    UBA_FAF1; UBA-like domain found in FAS-associated factor 1 (FAF1) and similar proteins

  2. NM_001299544.1 → NP_001286473.1  caspar, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286473.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFH2, F0JAP4
    Conserved Domains (4) summary
    cd01769
    Location:143 → 177
    UBL; Ubiquitin-like domain of UBL
    cd01771
    Location:611 → 690
    Faf1_UBX; Faf1 UBX domain
    cd02990
    Location:387 → 525
    UAS_FAF1; UAS family, FAS-associated factor 1 (FAF1) subfamily; FAF1 contains a UAS domain of unknown function N-terminal to a ubiquitin-associated UBX domain. FAF1 also contains ubiquitin-associated UBA and nuclear targeting domains, N-terminal to the UAS domain. ...
    cd14413
    Location:12 → 44
    UBA_FAF1; UBA-like domain found in FAS-associated factor 1 (FAF1) and similar proteins

  3. NM_137236.5 → NP_611080.1  caspar, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611080.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F0JAP4, Q7JUP3
    Related
    FBpp0086397
    Conserved Domains (4) summary
    cd01769
    Location:148 → 182
    UBL; Ubiquitin-like domain of UBL
    cd01771
    Location:616 → 695
    Faf1_UBX; Faf1 UBX domain
    cd02990
    Location:392 → 530
    UAS_FAF1; UAS family, FAS-associated factor 1 (FAF1) subfamily; FAF1 contains a UAS domain of unknown function N-terminal to a ubiquitin-associated UBX domain. FAF1 also contains ubiquitin-associated UBA and nuclear targeting domains, N-terminal to the UAS domain. ...
    cd14413
    Location:12 → 44
    UBA_FAF1; UBA-like domain found in FAS-associated factor 1 (FAF1) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFH2 A0A0B4LFH2
Q7JUP3 Q7JUP3
Q8T4G2 Q8T4G2

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