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Impbeta11 Importin beta11 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36732, updated on 4-Jan-2025

Summary

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Official Symbol
Impbeta11provided by FlyBase
Official Full Name
Importin beta11provided by FlyBase
Primary source
FLYBASE:FBgn0284254
Locus tag
Dmel_CG33139
See related
AllianceGenome:FB:FBgn0284254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33139; CG8212; Dmel\CG33139; Imp beta11; imp-beta11; impbeta11; l(2)SH0971; l(2)SH2 0971; Ranbp11; RanBP11
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytosol and nuclear envelope. Is expressed in adult head; embryonic/larval hypodermal muscle cell; embryonic/larval neuromuscular junction; and organism. Orthologous to human IPO11 (importin 11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Impbeta11 in Genome Data Viewer
Location:
52B5-52B5; 2-75 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15682719..15687415)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11570224..11574920)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase 14kD subunit 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43429 Neighboring gene uncharacterized protein Neighboring gene Centrosomal protein 89kDa Neighboring gene antisense RNA:CR44372 Neighboring gene Endoplasmic reticulum stress-associated serine protease Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biological significance of the importin-β family-dependent nucleocytoplasmic transport pathways. Kimura M, et al. Traffic, 2014 Jul. PMID 24766099
  2. Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila. Borkúti P, et al. Front Mol Biosci, 2022. PMID 36060241, Free PMC Article
  3. β-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila. Beachum AN, et al. Dev Biol, 2023 Feb. PMID 36450333, Free PMC Article
  4. The Ketel gene encodes a Drosophila homologue of importin-beta. Lippai M, et al. Genetics, 2000 Dec. PMID 11102382, Free PMC Article
  5. γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor. Restrepo LJ, et al. Dev Cell, 2022 Jul 11. PMID 35654038, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
importin beta11
Names
CG33139-PA
Impbeta11-PA
Ranbp11
importin-11
importin-beta11
lethal (2) SH0971
ran-binding protein 11

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15682719..15687415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176177.2 → NP_788357.1  importin beta11 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788357.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0Q2
    Related
    FBpp0086416
    Conserved Domains (2) summary
    smart00913
    Location:42 → 120
    IBN_N; Importin-beta N-terminal domain
    COG5657
    Location:23 → 768
    CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K0Q2 Q7K0Q2

Gene LinkOut

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