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Acad8 acyl-CoA dehydrogenase family, member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367196, updated on 9-Dec-2024

Summary

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Official Symbol
Acad8provided by RGD
Official Full Name
acyl-CoA dehydrogenase family, member 8provided by RGD
Primary source
RGD:1564209
See related
EnsemblRapid:ENSRNOG00000048164 AllianceGenome:RGD:1564209
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564209
Summary
Predicted to enable acyl-CoA dehydrogenase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in carboxylic acid catabolic process and lipid metabolic process. Predicted to be located in mitochondrion. Orthologous to human ACAD8 (acyl-CoA dehydrogenase family member 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 230.6), Kidney (RPKM 182.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acad8 in Genome Data Viewer
Location:
8q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (33641420..33665542, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (25382271..25406404, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (28023401..28044967, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene pescadillo ribosomal biogenesis factor 1, pseudogene 5 Neighboring gene beta-galactosidase-like protein Neighboring gene thymocyte nuclear protein 1 Neighboring gene VPS26 retromer complex component B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans. Nguyen TV, et al. Mol Genet Metab, 2002 Sep-Oct. PMID 12359132
  2. Comparative studies of Acyl-CoA dehydrogenases for monomethyl branched chain substrates in amino acid metabolism. Liu X, et al. Bioorg Chem, 2013 Apr. PMID 23474214
  3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Isobutyryl-CoA dehydrogenase did not show the isomerase activity.
    Title: Comparative studies of Acyl-CoA dehydrogenases for monomethyl branched chain substrates in amino acid metabolism.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
isobutyryl-CoA dehydrogenase, mitochondrial
NP_001385734.1
XP_038938216.1
XP_038938217.1
XP_038938218.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398805.1 → NP_001385734.1  isobutyryl-CoA dehydrogenase, mitochondrial

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZQL5
    Related
    ENSRNOP00000080808.1, ENSRNOT00000120030.2
    Conserved Domains (1) summary
    cd01162
    Location:37 → 410
    IBD; Isobutyryl-CoA dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    33641420..33665542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082288.2 → XP_038938216.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl09933
    Location:27 → 316
    ACAD; Acyl-CoA dehydrogenase

  2. XM_039082289.2 → XP_038938217.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl09933
    Location:1 → 211
    ACAD; Acyl-CoA dehydrogenase

  3. XM_039082290.2 → XP_038938218.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl09933
    Location:1 → 211
    ACAD; Acyl-CoA dehydrogenase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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