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SRPK SR Protein Kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36706, updated on 9-Dec-2024

Summary

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Official Symbol
SRPKprovided by FlyBase
Official Full Name
SR Protein Kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0286813
Locus tag
Dmel_CG8174
See related
AllianceGenome:FB:FBgn0286813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
abc; BcDNA:SD03158; CG8174; Dmel\CG8174; dSRPK; dSRPK1; fs(2)abc; mat(2)syn-F; mat(2)synPL63; srpk; srpk79D; syn-PL63
Summary
Enables protein serine/threonine kinase activity. Involved in oocyte karyosome formation and spindle assembly involved in female meiosis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic/larval midgut primordium; ganglia; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See SRPK in Genome Data Viewer
Location:
51F11-51F12; 2-74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15380724..15387851)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11268229..11275356)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene double parked Neighboring gene long non-coding RNA:CR45020 Neighboring gene Stac-like Neighboring gene Metchnikowin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. abnormal chromatin (abc), a maternal-effect locus in Drosophila melanogaster. Vessey KB, et al. J Cell Sci, 1991 Feb. PMID 1905300
  2. The role of SR protein kinases in regulating lipid storage in the Drosophila fat body. Mercier J, et al. Biochem Biophys Res Commun, 2023 Mar 15. PMID 36738578
  3. Conservation and Innovation: Versatile Roles for LRP4 in Nervous System Development. DePew AT, et al. J Dev Biol, 2021 Mar 14. PMID 33799485, Free PMC Article
  4. Co-transcriptional splicing facilitates transcription of gigantic genes. Fingerhut JM, et al. PLoS Genet, 2024 Jun. PMID 38870220, Free PMC Article
  5. The conserved kinase SRPK regulates karyosome formation and spindle microtubule assembly in Drosophila oocytes. Loh BJ, et al. J Cell Sci, 2012 Oct 1. PMID 22854045, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of SR protein kinases in regulating lipid storage in the Drosophila fat body.
    Title: The role of SR protein kinases in regulating lipid storage in the Drosophila fat body.
  2. SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity.
    Title: SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity.
  3. A loss of SRPK severely prevents microtubule assembly for acentrosomal spindles in mature oocytes.
    Title: The conserved kinase SRPK regulates karyosome formation and spindle microtubule assembly in Drosophila oocytes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in oocyte karyosome formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly involved in female meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
SR protein kinase
Names
CG8174-PA
CG8174-PB
CG8174-PC
CG8174-PD
CG8174-PE
SRPK-PA
SRPK-PB
SRPK-PC
SRPK-PD
SRPK-PE
cuaba
female sterile abnormal chromatin
NP_001260993.1
NP_001369087.1
NP_611034.2
NP_725458.1
NP_725459.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15380724..15387851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382195.1 → NP_001369087.1  SR protein kinase, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q7C8
    Conserved Domains (1) summary
    cl21453
    Location:600 → 763
    PKc_like; Protein Kinases, catalytic domain

  2. NM_166093.3 → NP_725458.1  SR protein kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725458.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G2J5W6, Q0E965
    Related
    FBpp0086515
    Conserved Domains (1) summary
    cd14136
    Location:600 → 763
    STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

  3. NM_001274064.2 → NP_001260993.1  SR protein kinase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260993.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF69, G2J5W6
    Conserved Domains (1) summary
    cd14136
    Location:600 → 763
    STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

  4. NM_137190.4 → NP_611034.2  SR protein kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611034.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G2J5W6, Q0E965
    Related
    FBpp0086516
    Conserved Domains (1) summary
    cd14136
    Location:600 → 763
    STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

  5. NM_166094.1 → NP_725459.1  SR protein kinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725459.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZA05, C5WLP3
    Related
    FBpp0086517, FBtr0087385
    Conserved Domains (1) summary
    cd14136
    Location:443 → 606
    STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF69 A0A0B4KF69
A0A6M3Q7C8 A0A6M3Q7C8
A1ZA05 A1ZA05
Q0E965 Q0E965
Q95SW3 Q95SW3
Q9GSP5 Q9GSP5

Gene LinkOut

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