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unc-5 unc-5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36703, updated on 9-Dec-2024

Summary

Official Symbol
unc-5provided by FlyBase
Official Full Name
unc-5provided by FlyBase
Primary source
FLYBASE:FBgn0034013
Locus tag
Dmel_CG8166
See related
AllianceGenome:FB:FBgn0034013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF7419; CG8166; CG8168; CT20824; Dmel\CG8166; dUnc5; Dunc5; Unc-5; UNC-5; unc5; Unc5; UNC5; Unc5d; UNC5D
Summary
Predicted to enable netrin receptor activity involved in chemorepulsion. Involved in neurogenesis; positive regulation of cell migration; and salivary gland boundary specification. Predicted to be located in membrane. Is expressed in several structures, including PNS glial cell; embryonic/larval dorsal vessel; larval internal muscle motor neurons; nerve; and visceral mesoderm derivative. Orthologous to several human genes including UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See unc-5 in Genome Data Viewer
Location:
51F7-51F11; 2-74 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15340472..15368300)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11227977..11255805)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44371 Neighboring gene Hormone receptor 51 Neighboring gene long non-coding RNA:CR44458 Neighboring gene long non-coding RNA:CR44459 Neighboring gene Pms2 Neighboring gene pseudo

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

mobile_element

  • Loc: 15340746-15349272 mobile_element_type = transposon:Tirant{}834

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables netrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables netrin receptor activity involved in chemorepulsion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in netrin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in salivary gland boundary specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
unc-5
Names
CG8166-PA
CG8166-PB
UNC5 protein
Unc-5
Uncoordinated5
unc-5-PA
unc-5-PB
unc-5-like
uncoordinated 5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15340472..15368300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299521.1NP_001286450.1  unc-5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286450.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TU8, Q9NBL0, Q9V7B5
    UniProtKB/TrEMBL
    A0A0B4LFH9
    Conserved Domains (5) summary
    smart00209
    Location:327379
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:233321
    I-set; Immunoglobulin I-set domain
    cd08781
    Location:9731064
    Death_UNC5-like; Death domain found in Uncoordinated-5 homolog family
    cl02517
    Location:655749
    ZU5; ZU5 domain
    cl11960
    Location:236321
    Ig; Immunoglobulin domain
  2. NM_137189.3NP_611033.2  unc-5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611033.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TU8, Q9NBL0, Q9V7B5
    UniProtKB/TrEMBL
    A0A0B4LFH9
    Related
    FBpp0086514
    Conserved Domains (5) summary
    smart00209
    Location:327379
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:233321
    I-set; Immunoglobulin I-set domain
    cd08781
    Location:9731064
    Death_UNC5-like; Death domain found in Uncoordinated-5 homolog family
    cl02517
    Location:655749
    ZU5; ZU5 domain
    cl11960
    Location:236321
    Ig; Immunoglobulin domain