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Fbxo7 F-box protein 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366854, updated on 27-Nov-2024

Summary

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Official Symbol
Fbxo7provided by RGD
Official Full Name
F-box protein 7provided by RGD
Primary source
RGD:1305648
See related
EnsemblRapid:ENSRNOG00000004637 AllianceGenome:RGD:1305648
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including enzyme binding activity; protein heterodimerization activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of mitophagy. Predicted to be located in several cellular components, including Lewy body core; Lewy body corona; and Lewy neurite. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 193.3), Adrenal (RPKM 173.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxo7 in Genome Data Viewer
Location:
7q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (19696951..19725180, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (17809224..17837549, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (23815246..23843505, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene synapsin III Neighboring gene uncharacterized LOC134479850 Neighboring gene uncharacterized LOC134479849 Neighboring gene U6 spliceosomal RNA Neighboring gene BPI fold containing family C Neighboring gene RNA 2',3'-cyclic phosphate and 5'-OH ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss of nuclear activity of the FBXO7 protein in patients with parkinsonian-pyramidal syndrome (PARK15). Zhao T, et al. PLoS One, 2011 Feb 11. PMID 21347293, Free PMC Article
  2. FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease. Chen CM, et al. PLoS One, 2014. PMID 25029497, Free PMC Article
  3. FBXO7 immunoreactivity in α-synuclein-containing inclusions in Parkinson disease and multiple system atrophy. Zhao T, et al. J Neuropathol Exp Neurol, 2013 Jun. PMID 23656991
  4. Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells. Meziane el K, et al. J Cell Sci, 2011 Jul 1. PMID 21652635
  5. The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. Chang YF, et al. Biochem Biophys Res Commun, 2006 Apr 21. PMID 16510124

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy of mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of locomotion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Lewy body core ISO
Inferred from Sequence Orthology
more info
  
located_in Lewy body corona ISO
Inferred from Sequence Orthology
more info
  
located_in Lewy neurite ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in classical Lewy body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in glial cytoplasmic inclusion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
F-box only protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012222.1 → NP_001012222.1  F-box only protein 7

    See identical proteins and their annotated locations for NP_001012222.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079382
    UniProtKB/Swiss-Prot
    Q68FS3
    UniProtKB/TrEMBL
    A6IFC7
    Related
    ENSRNOP00000006366.5, ENSRNOT00000006366.9
    Conserved Domains (5) summary
    PHA03247
    Location:422 → 515
    PHA03247; large tegument protein UL36; Provisional
    pfam06881
    Location:371 → 408
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam11566
    Location:193 → 317
    PI31_Prot_N; PI31 proteasome regulator N-terminal
    pfam12937
    Location:335 → 376
    F-box-like
    cl28922
    Location:1 → 77
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    19696951..19725180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079673.2 → XP_038935601.1  F-box only protein 7 isoform X2

    UniProtKB/TrEMBL
    A6IFC8
    Conserved Domains (4) summary
    PHA03247
    Location:284 → 377
    PHA03247; large tegument protein UL36; Provisional
    pfam06881
    Location:233 → 270
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam11566
    Location:55 → 179
    PI31_Prot_N; PI31 proteasome regulator N-terminal
    pfam12937
    Location:197 → 238
    F-box-like

  2. XM_006241166.4 → XP_006241228.1  F-box only protein 7 isoform X1

    Conserved Domains (3) summary
    pfam06881
    Location:292 → 329
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam11566
    Location:110 → 242
    PI31_Prot_N; PI31 proteasome regulator N-terminal
    pfam12937
    Location:256 → 299
    F-box-like; F-box-like

  3. XM_006241167.3 → XP_006241229.1  F-box only protein 7 isoform X3

    See identical proteins and their annotated locations for XP_006241229.1

    Conserved Domains (4) summary
    PHA03247
    Location:341 → 434
    PHA03247; large tegument protein UL36; Provisional
    pfam06881
    Location:290 → 327
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam11566
    Location:112 → 236
    PI31_Prot_N; PI31 proteasome regulator N-terminal
    pfam12937
    Location:254 → 295
    F-box-like

  4. XM_039079674.2 → XP_038935602.1  F-box only protein 7 isoform X2

    UniProtKB/TrEMBL
    A6IFC8
    Conserved Domains (4) summary
    PHA03247
    Location:284 → 377
    PHA03247; large tegument protein UL36; Provisional
    pfam06881
    Location:233 → 270
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam11566
    Location:55 → 179
    PI31_Prot_N; PI31 proteasome regulator N-terminal
    pfam12937
    Location:197 → 238
    F-box-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FS3.1 GenPept UniProtKB/Swiss-Prot:Q68FS3

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