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igl igloo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36681, updated on 9-Dec-2024

Summary

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Official Symbol
iglprovided by FlyBase
Official Full Name
iglooprovided by FlyBase
Primary source
FLYBASE:FBgn0013467
Locus tag
Dmel_CG18285
See related
AllianceGenome:FB:FBgn0013467
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18285; Dmel\CG18285; Igl
Summary
Enables calmodulin binding activity. Located in cell cortex. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic head sensory system; and sensory nervous system primordium. Orthologous to human GAP43 (growth associated protein 43) and SPA17 (sperm autoantigenic protein 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See igl in Genome Data Viewer
Location:
51E3-51E5; 2-74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15155437..15190292)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11042942..11077797)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43831 Neighboring gene uncharacterized protein Neighboring gene Seminal fluid protein 51E Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Igloo, a GAP-43-related gene expressed in the developing nervous system of Drosophila. Neel VA, et al. Development, 1994 Aug. PMID 7925024
  2. Calmodulin signaling via the IQ motif. Bähler M, et al. FEBS Lett, 2002 Feb 20. PMID 11911888
  3. Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signalling. Benetka W, et al. Cell Cycle, 2008 Dec. PMID 19029837
  4. Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types. Yeung K, et al. Commun Biol, 2022 Dec 14. PMID 36517671, Free PMC Article
  5. The Drosophila gene abnormal spindle encodes a novel microtubule-associated protein that associates with the polar regions of the mitotic spindle. Saunders RD, et al. J Cell Biol, 1997 May 19. PMID 9151690, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
igloo
Names
CG18285-PA
CG18285-PB
CG18285-PC
igl-PA
igl-PB
igl-PC
invertebrate GAP-43-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15155437..15190292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274059.1 → NP_001260988.1  igloo, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260988.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95T29
    Conserved Domains (2) summary
    smart00015
    Location:98 → 117
    IQ; Calmodulin-binding motif
    cd22307
    Location:51 → 91
    Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif

  2. NM_057712.5 → NP_477060.1  igloo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JPS2
    Related
    FBpp0086494
    Conserved Domains (2) summary
    smart00015
    Location:216 → 235
    IQ; Calmodulin-binding motif
    cd22307
    Location:74 → 129
    Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif

  3. NM_057713.5 → NP_477061.1  igloo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477061.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95T29
    Related
    FBpp0086495
    Conserved Domains (2) summary
    smart00015
    Location:98 → 117
    IQ; Calmodulin-binding motif
    cd22307
    Location:51 → 91
    Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JPS2 Q7JPS2
Q95T29 Q95T29

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