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pcs parcas [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36674, updated on 9-Dec-2024

Summary

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Official Symbol
pcsprovided by FlyBase
Official Full Name
parcasprovided by FlyBase
Primary source
FLYBASE:FBgn0033988
Locus tag
Dmel_CG7761
See related
AllianceGenome:FB:FBgn0033988
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7761; Dmel\CG7761; Pcs; prt
Summary
Enables guanyl-nucleotide exchange factor activity and protein tyrosine kinase inhibitor activity. Involved in several processes, including female germline ring canal formation; muscle cell fate specification; and muscle organ morphogenesis. Located in cytoplasm and plasma membrane. Is expressed in several structures, including anal pad primordium; anlage in statu nascendi; antennal anlage; central brain anlage; and mesoderm. Orthologous to human SH3BP5L (SH3 binding domain protein 5 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See pcs in Genome Data Viewer
Location:
51D6-51D7; 2-73 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14981263..14991336)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10868768..10878841)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene atypical protein kinase C Neighboring gene caskin Neighboring gene transfer RNA:Leucine-AAG 1-1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43830 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. REQUIREMENT OF THE TEC FAMILY TYROSINE KINASE BTK29A FOR COURTSHIP MEMORY IN Drosophila MALES. Sunouchi K, et al. Arch Insect Biochem Physiol, 2016 Mar. PMID 26782301
  2. Functional replacement of Drosophila Btk29A with human Btk in male genital development and survival. Hamada N, et al. FEBS Lett, 2005 Aug 1. PMID 16023106
  3. Btk29A-mediated tyrosine phosphorylation of armadillo/β-catenin promotes ring canal growth in Drosophila oogenesis. Hamada-Kawaguchi N, et al. PLoS One, 2015. PMID 25803041, Free PMC Article
  4. REI/SH3BP5 protein family: New GEFs for Rab11. Sato K, et al. Cell Cycle, 2016. PMID 26745340, Free PMC Article
  5. Recycling endosomes attach to the trans-side of Golgi stacks in Drosophila and mammalian cells. Fujii S, et al. J Cell Sci, 2020 Feb 26. PMID 31974113

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that both TRAPPII and Pcs are required for eye development, but Pcs functions as the predominant Rab11-GEF for post-Golgi transport to photosensitive membrane rhabdomeres.
    Title: Parcas is the predominant Rab11-GEF for rhodopsin transport in Drosophila photoreceptors.
  2. REI/SH3BP5 protein family is conserved in evolution and is a group of new guanine nucleotide exchange factors for Rab11.
    Title: REI/SH3BP5 protein family: New GEFs for Rab11.
  3. poirot, a new regulatory gene of Drosophila, regulates oskar mRNA localization in an isoform-specific manner.
    Title: poirot, a new regulatory gene of Drosophila oskar acts at the level of the short Oskar protein isoform.
  4. Pcs fulfils its distinct roles during development by the regulation of multiple non-receptor tyrosine kinase (NRTKs).
    Title: Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase inhibitor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female germline ring canal formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in mesoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
parcas
Names
CG7761-PB
parkas
pcs-PB
poirot

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14981263..14991336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137166.5 → NP_611010.4  parcas [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611010.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V785
    Conserved Domains (1) summary
    pfam05276
    Location:8 → 235
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V785.4 Q9V785

Gene LinkOut

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