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Pcf11 Pcf11 cleavage and polyadenylation factor subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36658, updated on 4-Jan-2025

Summary

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Official Symbol
Pcf11provided by FlyBase
Official Full Name
Pcf11 cleavage and polyadenylation factor subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0264962
Locus tag
Dmel_CG10228
See related
AllianceGenome:FB:FBgn0264962
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.146; CG10228; Dmel\CG10228; dPcf11; Inr-a; l(2)k08015; pcf11; PCF11
Summary
Enables RNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be part of mRNA cleavage factor complex. Predicted to be active in cytoplasm. Is expressed in spermatozoon. Orthologous to human PCF11 (PCF11 cleavage and polyadenylation factor subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Pcf11 in Genome Data Viewer
Location:
51C5-51C7; 2-72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14860936..14871071, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10748441..10758576, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Hermansky-Pudlak Syndrome 1 Neighboring gene uncharacterized protein Neighboring gene U3 small nuclear riboprotein factor 55K Neighboring gene Cytochrome P450 6a22 Neighboring gene Cytochrome P450 6a17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Inverse Regulator-a (Inr-a) as Synonymous with Pre-mRNA Cleavage Complex II Protein (Pcf11) in Drosophila. Xie W, et al. G3 (Bethesda), 2012 Jun. PMID 22690379, Free PMC Article
  2. A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila. Rabinow L, et al. Genetics, 1991 Oct. PMID 1743487, Free PMC Article
  3. Role of multiple trans-acting regulators in modifying the effect of the retrotransposon copia on host gene expression in Drosophila. Pal Bhadra M, et al. Mol Gen Genet, 1998 Aug. PMID 9747711
  4. A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage. Gallicchio L, et al. Genes Dev, 2024 Aug 20. PMID 39111825, Free PMC Article
  5. Interactions among dosage-dependent trans-acting modifiers of gene expression and position-effect variegation in Drosophila. Bhadra U, et al. Genetics, 1998 Sep. PMID 9725844, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes.
    Title: Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes.
  2. Data show that Pcf11 is directly involved in transcription termination in Drosophila.
    Title: Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II complex binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in termination of RNA polymerase II transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in termination of RNA polymerase II transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Pcf11 cleavage and polyadenylation factor subunit
Names
CG10228-PB
CG10228-PC
CG10228-PD
CG10228-PE
CG10228-PF
CG10228-PG
CG10228-PH
Pcf11-PB
Pcf11-PC
Pcf11-PD
Pcf11-PE
Pcf11-PF
Pcf11-PG
Pcf11-PH
inverse regulator a
lethal (2) k08015
protein 1 of cleavage and polyadenylation factor 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14860936..14871071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299501.1 → NP_001286430.1  Pcf11 cleavage and polyadenylation factor subunit, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286430.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFF9
    Conserved Domains (3) summary
    cd03562
    Location:17 → 134
    CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
    pfam00836
    Location:622 → 725
    Stathmin; Stathmin family
    pfam09032
    Location:187 → 255
    Siah-Interact_N; Siah interacting protein, N terminal

  2. NM_001202002.2 → NP_001188931.1  Pcf11 cleavage and polyadenylation factor subunit, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188931.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFF9
    Conserved Domains (3) summary
    cd03562
    Location:17 → 134
    CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
    pfam00836
    Location:622 → 725
    Stathmin; Stathmin family
    pfam09032
    Location:187 → 255
    Siah-Interact_N; Siah interacting protein, N terminal

  3. NM_001299499.1 → NP_001286428.1  Pcf11 cleavage and polyadenylation factor subunit, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286428.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF47
    Conserved Domains (3) summary
    cd03562
    Location:17 → 134
    CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
    pfam00836
    Location:633 → 736
    Stathmin; Stathmin family
    pfam09032
    Location:187 → 255
    Siah-Interact_N; Siah interacting protein, N terminal

  4. NM_001299500.1 → NP_001286429.1  Pcf11 cleavage and polyadenylation factor subunit, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286429.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFE6
    Conserved Domains (3) summary
    cd03562
    Location:17 → 134
    CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
    pfam00836
    Location:728 → 831
    Stathmin; Stathmin family
    pfam09032
    Location:187 → 255
    Siah-Interact_N; Siah interacting protein, N terminal

  5. NM_137155.5 → NP_610999.4  Pcf11 cleavage and polyadenylation factor subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610999.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9W4, C6SUY2
    Conserved Domains (3) summary
    cd03562
    Location:17 → 134
    CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
    pfam00836
    Location:736 → 839
    Stathmin; Stathmin family
    pfam09032
    Location:187 → 255
    Siah-Interact_N; Siah interacting protein, N terminal

  6. NM_001169682.2 → NP_001163153.1  Pcf11 cleavage and polyadenylation factor subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163153.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JH68, Q8IGR2
    Conserved Domains (2) summary
    cd03562
    Location:17 → 134
    CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
    pfam09032
    Location:187 → 255
    Siah-Interact_N; Siah interacting protein, N terminal

  7. NM_001169683.2 → NP_001163154.1  Pcf11 cleavage and polyadenylation factor subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163154.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0P8M6
    Conserved Domains (1) summary
    cl02544
    Location:17 → 62
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LF47 A0A0B4LF47
A0A0B4LFE6 A0A0B4LFE6
A0A0B4LFF9 A0A0B4LFF9
A1Z9W4 A1Z9W4
C0P8M6 C0P8M6
E1JH68 E1JH68
Q8IGR2 Q8IGR2

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