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Ciao1 Ciao1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36655, updated on 4-Jan-2025

Summary

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Official Symbol
Ciao1provided by FlyBase
Official Full Name
Ciao1provided by FlyBase
Primary source
FLYBASE:FBgn0033972
Locus tag
Dmel_CG12797
See related
AllianceGenome:FB:FBgn0033972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12797; CiaO1; CIAO1; Dmel\CG12797
Summary
Predicted to be involved in iron-sulfur cluster assembly. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle system; and larval visceral muscle cell. Orthologous to human CIAO1 (cytosolic iron-sulfur assembly component 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ciao1 in Genome Data Viewer
Location:
51C5-51C5; 2-72 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14853863..14855048, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10741368..10742553, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 2 Neighboring gene Ercc1 Neighboring gene Hermansky-Pudlak Syndrome 1 Neighboring gene uncharacterized protein Neighboring gene U3 small nuclear riboprotein factor 55K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A proteomics approach to identify targets of the ubiquitin-like molecule Urm1 in Drosophila melanogaster. Khoshnood B, et al. PLoS One, 2017. PMID 28953965, Free PMC Article
  2. Structural insights into Fe-S protein biogenesis by the CIA targeting complex. Kassube SA, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32632277
  3. Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila. Jung J, et al. Cell Death Dis, 2020 May 13. PMID 32404863, Free PMC Article
  4. Drosophila ERCC1 is required for a subset of MEI-9-dependent meiotic crossovers. Radford SJ, et al. Genetics, 2005 Aug. PMID 15944364, Free PMC Article
  5. Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster. Garlapow ME, et al. Behav Genet, 2017 Mar. PMID 27704301, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila.
    Title: Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in iron-sulfur cluster assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of cytosolic [4Fe-4S] assembly targeting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ciao1
Names
CG12797-PA
Ciao1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14853863..14855048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137152.4 → NP_610996.1  Ciao1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610996.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K1Y4
    Related
    FBpp0086590
    Conserved Domains (3) summary
    COG2319
    Location:9 → 333
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:6 → 332
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:17 → 57
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K1Y4.1 Q7K1Y4

Gene LinkOut

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