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Dhx57 DExH-box helicase 57 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366532, updated on 4-Jan-2025

Summary

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Official Symbol
Dhx57provided by RGD
Official Full Name
DExH-box helicase 57provided by RGD
Primary source
RGD:1310340
See related
EnsemblRapid:ENSRNOG00000054272 AllianceGenome:RGD:1310340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity and helicase activity. Orthologous to human DHX57 (DExH-box helicase 57). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 112.9), Adrenal (RPKM 97.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dhx57 in Genome Data Viewer
Location:
6q12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20474889..20528556)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14725305..14776321)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (2921340..2961397, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene uncharacterized LOC134479101 Neighboring gene eukaryotic translation initiation factor 4A2, pseudogene 2 Neighboring gene MORN repeat containing 2 Neighboring gene gem (nuclear organelle) associated protein 6 Neighboring gene tetratricopeptide repeat domain 39D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative ATP-dependent RNA helicase DHX57
Names
DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DEAH-box helicase 57
NP_001178836.1
XP_038968537.1
XP_038968538.1
XP_038968541.1
XP_038968543.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191907.2 → NP_001178836.1  putative ATP-dependent RNA helicase DHX57

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2JZH9
    Conserved Domains (4) summary
    COG1643
    Location:504 → 1301
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd14317
    Location:184 → 221
    UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
    pfam05773
    Location:249 → 422
    RWD; RWD domain
    pfam18345
    Location:308 → 326
    zf_CCCH_4; Zinc finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    20474889..20528556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112615.2 → XP_038968543.2  putative ATP-dependent RNA helicase DHX57 isoform X4

  2. XM_039112609.1 → XP_038968537.1  putative ATP-dependent RNA helicase DHX57 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZH9
    Related
    ENSRNOP00000071053.3, ENSRNOT00000090688.3
    Conserved Domains (4) summary
    COG1643
    Location:504 → 1301
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd14317
    Location:184 → 221
    UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
    pfam05773
    Location:249 → 422
    RWD; RWD domain
    pfam18345
    Location:308 → 326
    zf_CCCH_4; Zinc finger domain

  3. XM_039112610.1 → XP_038968538.1  putative ATP-dependent RNA helicase DHX57 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JZH9, A0A8I6A546
    Related
    ENSRNOP00000087092.2, ENSRNOT00000107942.2
    Conserved Domains (4) summary
    COG1643
    Location:451 → 1248
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd14317
    Location:131 → 168
    UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
    pfam05773
    Location:196 → 369
    RWD; RWD domain
    pfam18345
    Location:255 → 273
    zf_CCCH_4; Zinc finger domain

  4. XM_039112613.1 → XP_038968541.1  putative ATP-dependent RNA helicase DHX57 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JZH9
    Related
    ENSRNOP00000099483.1, ENSRNOT00000130652.1
    Conserved Domains (4) summary
    COG1643
    Location:398 → 1195
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd14317
    Location:78 → 115
    UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
    pfam05773
    Location:143 → 316
    RWD; RWD domain
    pfam18345
    Location:202 → 220
    zf_CCCH_4; Zinc finger domain
Nucleotide Protein Strain
Heading Accession and Version

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