Frrs1l ferric-chelate reductase 1-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Frrs1lprovided by RGD
Official Full Name: ferric-chelate reductase 1-likeprovided by RGD
Primary source: RGD:1309978
See related: EnsemblRapid:ENSRNOG00000043103 AllianceGenome:RGD:1309978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Epb4.1l4b
Summary: Predicted to enable dynein intermediate chain binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum membrane and postsynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 37. Orthologous to human FRRS1L (ferric chelate reductase 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 195.2), Spleen (RPKM 25.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (76451101..76485319, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (71655911..71690132, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (73997958..74029381, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH133118 (e-PCR)
- UniSTS:216401

RH134760 (e-PCR)
- UniSTS:218038

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DOMON domain-containing protein FRRS1L

Names: erythrocyte protein band 4.1-like 4b; ferric-chelate reductase 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419637.2 → NP_001406566.1 DOMON domain-containing protein FRRS1L precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

D3ZE85

Related

ENSRNOP00000031856.4, ENSRNOT00000031432.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

76451101..76485319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111411.2 → XP_038967339.1 DOMON domain-containing protein FRRS1L isoform X1

Conserved Domains (1) summary

cl14783
Location:94 → 160

DOMON_like; Domon-like ligand-binding domains